ArticlePloS one2013
Detection of synchronous cancers by fluorodeoxyglucose positron emission tomography/computed tomography during primary staging workup for esophageal squamous cell carcinoma in Taiwan.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 19 citations in OpenAlex.
- The value of [BMC medical imaging · 2025Article
- The role ofFrontiers in oncology · 2022Article
- Synchronous quadruple primary malignancies of the cervix, endometrium, ovary, and stomach in a single patient: A case report and review of literature.World journal of clinical cases · 2019Article
- A retrospective analysis of the treatment results for advanced synchronous head and neck and esophageal cancer.BJR open · 2019Article
- Lung cancer patients with synchronous colon cancer.Molecular and clinical oncology · 2018Article
- Article
- A first case report of rare synchronous double cancers: malignant cutaneous melanoma and gastrointestinal stromal tumor.Postepy dermatologii i alergologii · 2017Article
- Aberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma.Journal of biomedical science · 2017Article
- Incidence and risk factors of synchronous colorectal cancer in patients with esophageal cancer: an analysis of 480 consecutive colonoscopies before surgery.International journal of clinical oncology · 2016Article
- Clinical outcomes of synchronous head and neck and esophageal cancer.Radiation oncology journal · 2015Article
- Secondary primary malignancy risk among patients with esophageal cancer in Taiwan: a nationwide population-based study.PloS one · 2015Article
- RASSF5A, a candidate tumor suppressor, is epigenetically inactivated in esophageal squamous cell carcinoma.Clinical & experimental metastasis · 2015Article
- The role of ¹⁸F-FDG PET imaging in upper gastrointestinal malignancies.Current treatment options in oncology · 2014Review
- Squamous Esophageal Carcinoma Synchronous to Pericolic Malignant Conjunctive Tumor.Current health sciences journalArticle
- Conventional Western Treatment Associated With Chinese Herbal Medicine Ameliorates the Incidence of Head and Neck Cancer Among Patients With Esophageal Cancer.Integrative cancer therapiesArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of this retrospective study was to investigate the ability of fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in the detection of synchronous cancers during staging workup for esophageal squamous cell carcinoma. MATERIALS AND
methodsWe performed a retrospective chart review of 426 Taiwanese patients with esophageal cancer who received FDG-PET/CT during their primary staging workup between December 2006 and December 2011. We defined synchronous cancers as those occurring within 6 months of the FDG-PET/CT scan. All of the synchronous lesions were confirmed by histology or imaging follow-up. The study patients were followed for at least 18 months or were censored on the date of last follow-up.
resultsFifty patients were excluded from analysis because of the presence of distant metastases. Of the remaining 376 patients, 359 were diagnosed with squamous cell carcinoma (SCC). We identified 17 patients with synchronous cancers, and all of them had a diagnosis of SCC. Synchronous head and neck cancers were the most frequent (n=13, 76.4%), followed by gastrointestinal cancers (colon cancer, n=2; hepatocellular carcinoma, n=1), and renal cell carcinoma (n=1). FDG-PET/CT successfully detected 15 synchronous cancers (12 head and neck cancers, 2 colon cancers, and 1 renal cell carcinoma). In contrast, conventional workup detected only 9 synchronous cancers (7 head and neck cancers, 1 hepatocellular carcinoma and 1 renal cell carcinoma). The sensitivity of FDG-PET/CT and conventional workup in detecting synchronous cancers were 88.2% and 52.9% respectively.
conclusionThe most frequent synchronous lesions in patients with esophageal SCC were head and neck cancers in Taiwan. Our data indicate that FDG-PET/CT is superior to conventional workup in the detection of synchronous tumors during primary staging for esophageal squamous cell carcinoma.
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