ArticlePloS one2013
Identification and comparison of anti-inflammatory ingredients from different organs of Lotus nelumbo by UPLC/Q-TOF and PCA coupled with a NF-κB reporter gene assay.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Lotus Seeds: Current Molecular Biology Insights and Future Perspectives as a Prominent Biological Resource.Plants (Basel, Switzerland) · 2026Review
- Integrative analysis of the metabolome and transcriptome reveals the mechanism of flower color and antioxidant capacity in threeFrontiers in plant science · 2026Article
- Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier.Fluids and barriers of the CNS · 2024Review
- Liensinine reduces acute lung injury brought on by lipopolysaccharide by inhibiting the activation of the NF-κB signaling pathway through modification of the Src/TRAF6/TAK1 axis.Inflammopharmacology · 2024Article
- Lotus (Cancers · 2022Review
- A comparative review on the anti-nutritional factors of herbal tea concoctions and their reduction strategies.Frontiers in nutrition · 2022Review
- Phytochemicals and Immunomodulatory Effect ofPlants (Basel, Switzerland) · 2021Article
- Nelumbo genome database, an integrative resource for gene expression and variants of Nelumbo nucifera.Scientific data · 2021Article
- Sensitive Quantification of Liensinine Alkaloid Using a HPLC-MS/MS Method and Its Application in Microvolume Rat Plasma.Journal of analytical methods in chemistry · 2021Article
- Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening.Acta pharmaceutica Sinica. B · 2021Article
- Isolation and characterization of twoThe Journal of biological chemistry · 2020Article
- Preventive Effect of Alkaloids fromFoods (Basel, Switzerland) · 2019Article
- Benzylisoquinoline Alkaloids Biosynthesis in Sacred Lotus.Molecules (Basel, Switzerland) · 2018Review
- Investigation of benzylisoquinoline alkaloid biosynthetic pathway and its transcriptional regulation in lotus.Horticulture research · 2018Article
- Digital Gene Expression Analysis Provides Insight into the Transcript Profile of the Genes Involved in Aporphine Alkaloid Biosynthesis in Lotus (Frontiers in plant science · 2017Article
- Liensinine and Nuciferine, Bioactive Components ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- The Elevation of LC-ESI-Q-TOF-MS Response in the Analysis of Isoquinoline Alkaloids from Some Papaveraceae and Berberidaceae Representatives.Journal of analytical methods in chemistry · 2017Article
- Optimization of microwave-assisted extraction of bioactive alkaloids from lotus plumule using response surface methodology.Journal of pharmaceutical analysis · 2016Article
- A Simple, Rapid and Reliable Method to Determine Imipramine and Desipramine in Mouse Serum Using Ultra-High-Performance Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry.Journal of chromatographic science · 2016Article
- Current Advances in the Metabolomics Study on Lotus Seeds.Frontiers in plant science · 2016Review
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Authors and funding
9 authors.
Funding
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Abstract
Lotus nelumbo (LN) (Nelumbo nucifera Gaertn.) is an aquatic crop that is widely distributed throughout Asia and India, and various parts of this plant are edible and medicinal. It is noteworthy that different organs of this plant are used in traditional herbal medicine or folk recipes to cure different diseases and to relieve their corresponding symptoms. The compounds that are contained in each organ, which are named based on their chemical compositions, have led to their respective usages. In this work, a strategy was used to identify the difference ingredients and screen for Nuclear-factor-kappaB (NF-κB) inhibitors with anti-inflammatory ability in LN. Seventeen main difference ingredients were compared and identified from 64 samples of 4 different organs by ultra-performance liquid chromatography that was coupled with quadrupole/time of flight mass spectrometry (UPLC/Q-TOF-MS) with principal component analysis (PCA). A luciferase reporter assay system combined with the UPLC/Q-TOF-MS information was applied to screen biologically active substances. Ten NF-κB inhibitors from Lotus plumule (LP) extracts, most of which were isoquinoline alkaloids or flavone C-glycosides, were screened. Heat map results showed that eight of these compounds were abundant in the LP. In conclusion, the LP extracts were considered to have the best anti-inflammatory ability of the four LN organs, and the chemical material basis (CMB) of this biological activity was successfully validated by multivariate statistical analysis and biological research methods.
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