Trial reportPloS one2013
Effect of replacing sugar with non-caloric sweeteners in beverages on the reward value after repeated exposure.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- A Systematic Review and Activation Likelihood Estimation Meta-Analysis of fMRI Studies on Sweet Taste in Humans.The Journal of nutrition · 2020Pooled it
- Neural Mechanisms and Alterations of Sweet Sensing: Insights from Functional Magnetic Resonance Imaging Studies.Life (Basel, Switzerland) · 2025Review
- Article
- The Effects of Non-Nutritive Sweetener Consumption in the Pediatric Populations: What We Know, What We Don't, and What We Need to Learn.Frontiers in endocrinology · 2021Review
- Review
- CROCUFID: A Cross-Cultural Food Image Database for Research on Food Elicited Affective Responses.Frontiers in psychology · 2019Article
- Low-Calorie Sweeteners in Foods, Beverages, and Food and Beverage Additions: NHANES 2007-2012.Current developments in nutrition · 2018Article
- It's in the eye of the beholder: selective attention to drink properties during tasting influences brain activation in gustatory and reward regions.Brain imaging and behavior · 2018Article
- Methods for Evaluating Emotions Evoked by Food Experiences: A Literature Review.Frontiers in psychology · 2018Review
- The cephalic phase insulin response to nutritive and low-calorie sweeteners in solid and beverage form.Physiology & behavior · 2017Article
- Ecological correlations of dietary food intake and mental health disorders.Journal of epidemiology and global health · 2017Article
- Recent studies of the effects of sugars on brain systems involved in energy balance and reward: Relevance to low calorie sweeteners.Physiology & behavior · 2016Review
- Sugar consumption, metabolic disease and obesity: The state of the controversy.Critical reviews in clinical laboratory sciences · 2016Review
- Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism.Physiology & behavior · 2015Review
- Expected Satiety: Application to Weight Management and Understanding Energy Selection in Humans.Current obesity reports · 2015Review
- Altered food-cue processing in chronically ill and recovered women with anorexia nervosa.Frontiers in behavioral neuroscience · 2015Article
- Neural Processing of Calories in Brain Reward Areas Can be Modulated by Reward Sensitivity.Frontiers in behavioral neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe reward value of food is partly dependent on learned associations. It is not yet known whether replacing sugar with non-caloric sweeteners in food is affecting long-term acceptance.
objectiveTo determine the effect of replacing sugar with non-caloric sweeteners in a nutrient-empty drink (soft drink) versus nutrient-rich drink (yoghurt drink) on reward value after repeated exposure.
designWe used a randomized crossover design whereby forty subjects (15 men, 25 women) with a mean ± SD age of 21 ± 2 y and BMI of 21.5 ± 1.7 kg/m(2) consumed a fixed portion of a non-caloric sweetened (NS) and sugar sweetened (SS) versions of either a soft drink or a yoghurt drink (counterbalanced) for breakfast which were distinguishable by means of colored labels. Each version of a drink was offered 10 times in semi-random order. Before and after conditioning the reward value of the drinks was assessed using behavioral tasks on wanting, liking, and expected satiety. In a subgroup (n=18) fMRI was performed to assess brain reward responses to the drinks.
resultsOutcomes of both the behavioral tasks and fMRI showed that conditioning did not affect the reward value of the NS and SS versions of the drinks significantly. Overall, subjects preferred the yoghurt drinks to the soft drinks and the ss drinks to the NS drinks. In addition, they expected the yoghurt drinks to be more satiating, they reduced hunger more, and delayed the first eating episode more. Conditioning did not influence these effects.
conclusionOur study showed that repeated consumption of a non-caloric sweetened beverage, instead of a sugar sweetened version, appears not to result in changes in the reward value. It cannot be ruled out that learned associations between sensory attributes and food satiating capacity which developed preceding the conditioning period, during lifetime, affected the reward value of the drinks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.