ArticlePloS one2013
Blood erythrocyte concentrations of cadmium and lead and the risk of B-cell non-Hodgkin's lymphoma and multiple myeloma: a nested case-control study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Blood levels of cadmium and lead in relation to breast cancer risk in three prospective cohorts.International journal of cancer · 2019Pooled it
- Lead and cancer: a narrative review and risk of bias assessment (2003-2020).Reviews on environmental health · 2026Review
- Evidence for Genotype-Specific Optimal Blood Lead Levels for Cancer Risk:International journal of molecular sciences · 2026Article
- Blood Lead (Pb) Levels as a Possible Marker of Cancer Risk in a Prospective Cohort of Women with Non-Occupational Exposure.Biomedicines · 2025Article
- Blood Cadmium Level Is a Marker of Cancer Risk in Men.Nutrients · 2024Article
- Article
- Peripheral T-cell lymphoma of the oral cavity: A case report.Cancer reports (Hoboken, N.J.) · 2023Article
- Lead-exposure associated miRNAs in humans and Alzheimer's disease as potential biomarkers of the disease and disease processes.Scientific reports · 2022Article
- Risk of bladder cancer and lymphoma in dogs is associated with pollution indices by county of residence.Veterinary and comparative oncology · 2022Article
- Optimization of a GF-AAS method for lead testing in blood and urine: A useful tool in acute abdominal pain management in emergency.Experimental and therapeutic medicine · 2021Article
- Metabolomic signatures of lead exposure in the VA Normative Aging Study.Environmental research · 2020Article
- A heavy metal baseline score predicts outcome in acute myeloid leukemia.American journal of hematology · 2020Article
- Blood Transcriptome Response to Environmental Metal Exposure Reveals Potential Biological Processes Related to Alzheimer's Disease.Frontiers in public health · 2020Article
- Disparities in the Concentrations of Essential/Toxic Elements in the Blood and Scalp Hair of Lymphoma Patients and Healthy Subjects.Scientific reports · 2019Article
- Determinants of Erythrocyte Lead Levels in 454 Adults in Florence, Italy.International journal of environmental research and public health · 2019Article
- Interactive Effects between Chronic Lead Exposure and the Homeostatic Iron Regulator TransportInternational journal of environmental research and public health · 2019Article
- Effect of dietary supplement from mono-culture fermentation ofFood science & nutrition · 2018Article
- Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study.Environmental health : a global access science source · 2017Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCadmium (Cd) and lead (Pb) are hypothesised to be risk factors for non-Hodgkin's lymphoma (NHL), a group of haematological malignancies with a suspected environmental aetiology. Within the EnviroGenoMarkers study we utilised pre-diagnostic erythrocyte concentrations of Cd and Pb to determine whether exposure was associated with risk of B-cell NHL and multiple myeloma.
methods194 incident cases of B-cell NHL and 76 cases of multiple myeloma diagnosed between 1990 and 2006 were identified from two existing cohorts; EPIC-Italy and the Northern Sweden Health and Disease Study. Cases were matched to healthy controls by centre, age, gender and date of blood collection. Cd and Pb were measured in blood samples provided at recruitment using inductively coupled plasma-mass spectrometry. Logistic regression was applied to assess the association with risk. Analyses were stratified by cohort and gender and by subtype where possible.
resultsThere was little evidence of an increased risk of B-cell NHL or multiple myeloma with exposure to Cd (B-cell NHL: OR 1.09 95%CI 0.61, 1.93, MM: OR 1.16 95% CI: 0.40, 3.40 ) or Pb (B-cell NHL: 0.93 95% CI 0.43, 2.02, multiple myeloma: OR 1.63 95%CI 0.45, 5.94) in the total population when comparing the highest to the lowest quartile of exposure. However, gender and cohort specific differences in results were observed. In females the risk of B-cell NHL was more than doubled in those with a body burden of Cd >1 µg/L (OR 2.20 95%CI; 1.04, 4.65).
conclusionsThis nested case-control study does not support a consistent positive association between Cd or Pb and NHL, but there is some indication of a gender specific effect suggesting further research is warranted.
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