ArticlePloS one2013
Transcription profiling reveals potential mechanisms of dysbiosis in the oral microbiome of rhesus macaques with chronic untreated SIV infection.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Human immunodeficiency virus and oral microbiota: mutual influence on the establishment of a viral gingival reservoir in individuals under antiretroviral therapy.Frontiers in cellular and infection microbiology · 2024Review
- Gingival Transcriptome of Innate Antimicrobial Factors and the Oral Microbiome With Aging and Periodontitis.Frontiers in oral health · 2022Article
- Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection.Scientific reports · 2021Article
- Oral microbiome interactions with gingival gene expression patterns for apoptosis, autophagy and hypoxia pathways in progressing periodontitis.Immunology · 2021Article
- Article
- Oral Microbiome and Gingival Transcriptome Profiles of Ligature-Induced Periodontitis.Journal of dental research · 2020Article
- Article
- Microbiota fingerprints within the oral cavity of cetaceans as indicators for population biomonitoring.Scientific reports · 2019Article
- Microbiome Profiles of Ligature-Induced Periodontitis in Nonhuman Primates across the Life Span.Infection and immunity · 2019Article
- Clinical and microbiological parameters of naturally occurring periodontitis in the non-human primateJournal of oral microbiology · 2017Article
- Gut immune dysfunction through impaired innate pattern recognition receptor expression and gut microbiota dysbiosis in chronic SIV infection.Mucosal immunology · 2016Article
- Effects of aging in the expression of NOD-like receptors and inflammasome-related genes in oral mucosa.Molecular oral microbiology · 2016Article
- Commensal Streptococcus mitis is a unique vector for oral mucosal vaccination.Microbes and infection · 2015Article
- Microbiome in human immunodeficiency virus infection.Clinics in laboratory medicine · 2014Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
A majority of individuals infected with human immunodeficiency virus (HIV) have inadequate access to antiretroviral therapy and ultimately develop debilitating oral infections that often correlate with disease progression. Due to the impracticalities of conducting host-microbe systems-based studies in HIV infected patients, we have evaluated the potential of simian immunodeficiency virus (SIV) infected rhesus macaques to serve as a non-human primate model for oral manifestations of HIV disease. We present the first description of the rhesus macaque oral microbiota and show that a mixture of human commensal bacteria and "macaque versions" of human commensals colonize the tongue dorsum and dental plaque. Our findings indicate that SIV infection results in chronic activation of antiviral and inflammatory responses in the tongue mucosa that may collectively lead to repression of epithelial development and impact the microbiome. In addition, we show that dysbiosis of the lingual microbiome in SIV infection is characterized by outgrowth of Gemella morbillorum that may result from impaired macrophage function. Finally, we provide evidence that the increased capacity of opportunistic pathogens (e.g. E. coli) to colonize the microbiome is associated with reduced production of antimicrobial peptides.
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