ArticlePloS one2013
Estimating influenza deaths in Canada, 1992-2009.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07161739 (Vaccination Nudges Project), which is not on this map. Cited by 54 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vaccination Nudges Project: Behavioural Nudges From Pharmacists to Increase Influenza and Travel Vaccination Uptake: A Pragmatic Randomized Control Trial.
Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Sex differences in adverse events following seasonal influenza vaccines: a meta-analysis of randomised controlled trials.Journal of epidemiology and community health · 2023Pooled it
- Influenza-associated disease burden in mainland China: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Heterogeneity in Estimates of the Impact of Influenza on Population Mortality: A Systematic Review.American journal of epidemiology · 2018Pooled it
- Hospital burden of influenza, respiratory syncytial virus, and other respiratory viruses in Canada, seasons 2010/2011 to 2018/2019.Canadian journal of public health = Revue canadienne de sante publique · 2026Article
- Influenza Activity and Preterm Birth in the Atlanta Metropolitan Area: A Time-Series Analysis from 2010 to 2017.Epidemiology (Cambridge, Mass.) · 2025Article
- Summary of the National Advisory Committee on Immunization (NACI) Seasonal Influenza Vaccine Statement for 2024-2025.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2024Article
- Summary of the National Advisory Committee on Immunization (NACI) Seasonal Influenza Vaccine Statement for 2023-2024.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2023Article
- Healthy adults supplemented with a nutraceutical formulation containingFrontiers in nutrition · 2023Article
- Article
- Antigenic drift and epidemiological severity of seasonal influenza in Canada.Scientific reports · 2022Article
- Summary of the National Advisory Committee on Immunization (NACI) Seasonal Influenza Vaccine Statement for 2022-2023.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2022Article
- Article
- Predictors of Influenza Vaccination in Early Rheumatoid Arthritis 2017-2021: Results From the Canadian Early Arthritis Cohort.ACR open rheumatology · 2022Article
- Trends in Excess Winter Mortality (EWM) from 1900/01 to 2019/20-Evidence for a Complex System of Multiple Long-Term Trends.International journal of environmental research and public health · 2022Article
- National FluWatch mid-season report, 2021-2022: Sporadic influenza activity returns.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2022Article
- Projected impact of a plant-derived vaccine on the burden of seasonal influenza in Canada.Human vaccines & immunotherapeutics · 2021Article
- Article
- Helping Québec Pharmacists Seize the Vaccination Service Opportunity: The Pharmacy Best Practice Workshops.Pharmacy (Basel, Switzerland) · 2021Article
- Summary of the NACI Seasonal Influenza Vaccine Statement for 2020-2021.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2020Article
- State-level estimates of excess hospitalizations and deaths associated with influenza.Influenza and other respiratory viruses · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPoisson regression modelling has been widely used to estimate the disease burden attributable to influenza, though not without concerns that some of the excess burden could be due to other causes. This study aims to provide annual estimates of the mortality and hospitalization burden attributable to both seasonal influenza and the 2009 A/H1N1 pandemic influenza for Canada, and to discuss issues related to the reliability of these estimates.
methodsWeekly time-series for all-cause mortality and regression models were used to estimate the number of deaths in Canada attributable to influenza from September 1992 to December 2009. To assess their robustness, the annual estimates derived from different parameterizations of the regression model for all-cause mortality were compared. In addition, the association between the annual estimates for mortality and hospitalization by age group, underlying cause of death or primary reason for admission and discharge status is discussed.
resultsThe crude influenza-attributed mortality rate based on all-cause mortality and averaged over 17 influenza seasons prior to the 2009 A/H1N1 pandemic was 11.3 (95%CI, 10.5 - 12.1) deaths per 100 000 population per year, or an average of 3,500 (95%CI, 3,200 - 3,700) deaths per year attributable to seasonal influenza. The estimated annual rates ranged from undetectable at the ecological level to more than 6000 deaths per year over the three A/Sydney seasons. In comparison, we attributed an estimated 740 deaths (95%CI, 350-1500) to A(H1N1)pdm09. Annual estimates from different model parameterizations were strongly correlated, as were estimates for mortality and morbidity; the higher A(H1N1)pdm09 burden in younger age groups was the most notable exception.
interpretationWith the exception of some of the Serfling models, differences in the ecological estimates of the disease burden attributable to influenza were small in comparison to the variation in disease burden from one season to another.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.