ArticleClinical & developmental immunology2013
An elucidation of neutrophil functions against Mycobacterium tuberculosis infection.
Article in Clinical & developmental immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- It Takes a Village: The Multifaceted Immune Response toFrontiers in immunology · 2022Review
- Understanding the Relationship between Glutathione, TGF-β, and Vitamin D in CombatingJournal of clinical medicine · 2020Review
- Review
- Immunometabolism of Phagocytes DuringFrontiers in molecular biosciences · 2019Review
- Characterizing the Effects of Glutathione as an Immunoadjuvant in the Treatment of Tuberculosis.Antimicrobial agents and chemotherapy · 2018Article
- IL-17 Production of Neutrophils Enhances Antibacteria Ability but Promotes Arthritis Development During Mycobacterium tuberculosis Infection.EBioMedicine · 2017Article
- Effector Mechanisms of Neutrophils within the Innate Immune System in Response to Mycobacterium tuberculosis Infection.Journal of clinical medicine · 2017Review
- Article
- Liposomal Glutathione Supplementation Restores TH1 Cytokine Response to Mycobacterium tuberculosis Infection in HIV-Infected Individuals.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2015Article
- B in TB: B Cells as Mediators of Clinically Relevant Immune Responses in Tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Review
- Commentary to "Randomized controlled trial of oral glutathione supplementation on body stores of glutathione".European journal of nutrition · 2015Article
- Host directed therapies (HDTs) and immune response signatures: insights into a role for interleukin-32.Annals of translational medicine · 2015Article
- N-acetylcysteine as an add-on to Directly Observed Therapy Short-I therapy in fresh pulmonary tuberculosis patients: A randomized, placebo-controlled, double-blinded study.Perspectives in clinical researchArticle
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We characterized the functions of neutrophils in response to Mycobacterium tuberculosis (M. tb) infection, with particular reference to glutathione (GSH). We examined the effects of GSH in improving the ability of neutrophils to control intracellular M. tb infection. Our findings indicate that increasing the intracellular levels of GSH with a liposomal formulation of GSH (L-GSH) resulted in reduction in the levels of free radicals and increased acidification of M. tb containing phagosomes leading to the inhibition in the growth of M. tb. This inhibitory mechanism is dependent on the presence of TNF-α and IL-6. Our studies demonstrate a novel regulatory mechanism adapted by the neutrophils to control M. tb infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.