ReviewFrontiers in plant science2013
Is the fluid mosaic (and the accompanying raft hypothesis) a suitable model to describe fundamental features of biological membranes? What may be missing?
Review in Frontiers in plant science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Characterization and Computational Engineering of Structural Elements Controlling Gas Permeability in PIP2;1 Aquaporins.Journal of computational chemistry · 2026Article
- Lipid rafts, caveolae, and epidermal growth factor receptor family: friends or foes?Cell communication and signaling : CCS · 2024Review
- Eukaryotic Cell Membranes: Structure, Composition, Research Methods and Computational Modelling.International journal of molecular sciences · 2023Review
- Article
- Strength in numbers: effect of protein crowding on the shape of cell membranes.Biochemical Society transactions · 2022Review
- The Exploration of theFrontiers in microbiology · 2022Article
- Lipid Self-Assemblies under the Atomic Force Microscope.International journal of molecular sciences · 2021Review
- Compartmentalization of phosphatidylinositol 4,5-bisphosphate metabolism into plasma membrane liquid-ordered/raft domains.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Lipid Dependence of Xanthophyll Cycling in Higher Plants and Algae.Frontiers in plant science · 2020Review
- StarD5: an ER stress protein regulates plasma membrane and intracellular cholesterol homeostasis.Journal of lipid research · 2019Article
- Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.Chemical reviews · 2019Article
- Lipid Phases and Cell Geometry During the Cell Cycle ofFrontiers in microbiology · 2019Article
- The mystery of membrane organization: composition, regulation and roles of lipid rafts.Nature reviews. Molecular cell biology · 2017Review
- Spectral phasor analysis of LAURDAN fluorescence in live A549 lung cells to study the hydration and time evolution of intracellular lamellar body-like structures.Biochimica et biophysica acta · 2016Article
- Membrane curvature in cell biology: An integration of molecular mechanisms.The Journal of cell biology · 2016Review
- Effects of Dipole Potential Modifiers on Heterogenic Lipid Bilayers.The Journal of membrane biology · 2016Article
- Eisosomes are dynamic plasma membrane domains showing pil1-lsp1 heteroligomer binding equilibrium.Biophysical journal · 2015Article
- Differential effect of plant lipids on membrane organization: specificities of phytosphingolipids and phytosterols.The Journal of biological chemistry · 2015Article
- Arabidopsis ribosomal proteins control vacuole trafficking and developmental programs through the regulation of lipid metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Review
Corrections and comments
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2 authors.
Funding
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Abstract
The structure, dynamics, and stability of lipid bilayers are controlled by thermodynamic forces, leading to overall tensionless membranes with a distinct lateral organization and a conspicuous lateral pressure profile. Bilayers are also subject to built-in curvature-stress instabilities that may be released locally or globally in terms of morphological changes leading to the formation of non-lamellar and curved structures. A key controller of the bilayer's propensity to form curved structures is the average molecular shape of the different lipid molecules. Via the curvature stress, molecular shape mediates a coupling to membrane-protein function and provides a set of physical mechanisms for formation of lipid domains and laterally differentiated regions in the plane of the membrane. Unfortunately, these relevant physical features of membranes are often ignored in the most popular models for biological membranes. Results from a number of experimental and theoretical studies emphasize the significance of these fundamental physical properties and call for a refinement of the fluid mosaic model (and the accompanying raft hypothesis).
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