ArticleFrontiers in human neuroscience2013
On the evolution of the serotonin transporter linked polymorphic region (5-HTTLPR) in primates.
Article in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Spatiotemporal expression patterns of anxiety disorder-associated genes.Translational psychiatry · 2023Article
- A biocultural approach to psychiatric illnesses.Psychopharmacology · 2019Review
- Serotonin Receptor 1A Variation Is Associated with Anxiety and Agonistic Behavior in Chimpanzees.Molecular biology and evolution · 2019Article
- Differences in how macaques monitor others: Does serotonin play a central role?Wiley interdisciplinary reviews. Cognitive science · 2019Review
- Positive and balancing selection onEvolution letters · 2018Article
- Adaptive developmental plasticity in rhesus macaques: the serotonin transporter gene interacts with maternal care to affect juvenile social behaviour.Proceedings. Biological sciences · 2018Article
- Persistent social isolation reflects identity and social context but not maternal effects or early environment.Scientific reports · 2017Article
- Neuroendocrine control in social relationships in non-human primates: Field based evidence.Hormones and behavior · 2017Review
- Serotonin Transporter Gene Polymorphisms and Early Parent-Infant Interactions Are Related to Adult Male Heart Rate Response to Female Crying.Frontiers in physiology · 2017Article
- 5-HTTLPR polymorphism is linked to neural mechanisms of selective attention in preschoolers from lower socioeconomic status backgrounds.Developmental cognitive neuroscience · 2016Article
- Insights into the genetic foundation of aggression in Papio and the evolution of two length-polymorphisms in the promoter regions of serotonin-related genes (5-HTTLPR and MAOALPR) in Papionini.BMC evolutionary biology · 2016Article
- Differential serotonergic innervation of the amygdala in bonobos and chimpanzees.Social cognitive and affective neuroscience · 2016Article
- Native American ancestry leads to complexity in 5-HTTLPR polymorphism association studies.Molecular psychiatry · 2015Article
- Genetic influences on social attention in free-ranging rhesus macaques.Animal behaviour · 2015Article
- Searching for ancient balanced polymorphisms shared between Neanderthals and Modern Humans.Genetics and molecular biologyArticle
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Authors and funding
2 authors at 2 institutions in 1 country.
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Abstract
Some allelic variants of the serotonin transporter linked polymorphic region (5-HTTLPR) result in lower levels of expression of the serotonin transporter gene (SLC6A4). These low-expressing (LE) alleles are associated with mental-health disorders in a minority of humans that carry them. Humans are not the only primates that exhibit this polymorphism; other species, including some monkeys, also have LE and high-expressing (HE) variants of 5-HTTLPR. We propose a behavioral genetic framework to explain the adaptive evolution of this polymorphism in primates, including humans. We hypothesize that both LE and HE alleles are maintained by balancing selection in species characterized by short-term fluctuations in social competition levels. More specifically, we propose that LE carriers benefit from their hypervigilant tendencies during periods of elevated competition, whereas HE homozygotes cope best when competition levels do not deviate from the norm. Thus, both alleles have long-term benefits when competition levels tend to vary substantially over relatively short timescales within a social group. We describe this hypothesis in detail and outline a series of predictions to test it. Some of these predictions are supported by findings in the current literature, while others remain areas of future research.
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