ArticleFrontiers in integrative neuroscience2013
Habituation of reflexive and motivated behavior in mice with deficient BK channel function.
Article in Frontiers in integrative neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
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- Acoustic startle modification as a tool for evaluating auditory function of the mouse: Progress, pitfalls, and potential.Neuroscience and biobehavioral reviews · 2017Review
- Sensory processing in autism spectrum disorders and Fragile X syndrome-From the clinic to animal models.Neuroscience and biobehavioral reviews · 2017Review
- BK Channels Mediate Synaptic Plasticity Underlying Habituation in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Cereblon in health and disease.Pflugers Archiv : European journal of physiology · 2016Review
- Verapamil Parameter- and Dose-Dependently Impairs Memory Consolidation in Open Field Habituation Task in Rats.Frontiers in pharmacology · 2016Article
- The HIV-1 transgenic rat model of neuroHIV.Brain, behavior, and immunity · 2015Review
- A genome-wide screen identifies PAPP-AA-mediated IGFR signaling as a novel regulator of habituation learning.Neuron · 2015Article
- Habituation mechanisms and their importance for cognitive function.Frontiers in integrative neuroscience · 2014Article
- Longterm-habituation of the startle response in mice is stimulus modality, but not context specific.Frontiers in integrative neuroscience · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Habituation is considered the most basic form of learning. It describes the decrease of a behavioral response to a repeated non-threatening sensory stimulus and therefore provides an important sensory filtering mechanism. While some neuronal pathways mediating habituation are well described, underlying cellular/molecular mechanisms are not yet fully understood. In general, there is an agreement that short-term and long-term habituation are based on different mechanisms. Historically, a distinction has also been made between habituation of motivated versus reflexive behavior. In recent studies in invertebrates the large conductance voltage- and calcium-activated potassium (BK) channel has been implicated to be a key player in habituation by regulating synaptic transmission. Here, we tested mice deficient for the pore forming α-subunit of the BK channel for short-term and long-term habituation of the acoustic startle reflex (reflexive behavior) and of the exploratory locomotor behavior in the open field box (motivated behavior). Short-term habituation of startle was completely abolished in the BK knock-out mice, whereas neither long-term habituation of startle nor habituation of motivated behavior was affected by the BK deficiency. Our results support a highly preserved mechanism for short-term habituation of startle across species that is distinct from long-term habituation mechanisms. It also supports the notion that there are different mechanisms underlying habituation of motivated behavior versus reflexive behavior.
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