ArticleMicrobiologyOpen2013
Spoligotyping and drug resistance patterns of Mycobacterium tuberculosis isolates from five provinces of Iran.
Article in MicrobiologyOpen, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genotypic diversity of multi- and extensively drug-resistant Mycobacterium tuberculosis in Iran: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Variation in Mycobacterium tuberculosis population structure in Iran: a systemic review and meta-analysis.BMC infectious diseases · 2021Pooled it
- Molecular Characterization ofHealth science reports · 2026Article
- Antimicrobial resistance profile and prevalence ofJournal of clinical tuberculosis and other mycobacterial diseases · 2024Article
- Determination of genetic diversity of multidrug-resistantPathogens and global health · 2023Article
- Prevalence and molecular characterization of Mycobacterium tuberculosis complex in cattle and humans, Maiduguri, Borno state, Nigeria: a cross-sectional study.BMC microbiology · 2023Article
- Microbiological Investigations of Fine Needle Aspirates from Newly Suspected and Previously Treated Tubercular Lymphadenitis Patients.Infection and drug resistance · 2023Article
- Genotyping and drug susceptibility testing ofNew microbes and new infections · 2020Article
- There is significant relationship between Beijing genotype family strains and resistance to the first-line anti-tuberculosis drugs in the Iranian population.Journal of clinical tuberculosis and other mycobacterial diseases · 2020Article
- Spoligotype and Drug Susceptibility Profiles ofInfection and drug resistance · 2020Article
- Enhancing the differentiation of specific genotypes in Mycobacterium tuberculosis population.Scientific reports · 2019Article
- Spoligotype-based population structure of Mycobacterium tuberculosis in the Jimma Zone, southwest Ethiopia.MicrobiologyOpen · 2019Article
- One Health approach in the prevention and control of mycobacterial infections in Tanzania: lessons learnt and future perspectives.One health outlook · 2019Review
- Resistance ofHeliyon · 2019Article
- Article
- High genetic diversity amongJournal of clinical tuberculosis and other mycobacterial diseases · 2018Article
- Genetic Diversity of Drug-resistantAdvanced biomedical research · 2018Article
- The high prevalence ofIranian journal of microbiology · 2017Article
- Emerging and re-emerging infectious diseases in Iran.Iranian journal of microbiology · 2017Review
- Molecular typing methods used in studies ofIranian journal of microbiology · 2016Review
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Tuberculosis (TB) persists as a public health problem in Iran. Characterization of Mycobacterium tuberculosis isolates circulating in this area will contribute to understand and control the spread of the strains. The aims of this study were to understand the genetic diversity and drug susceptibility of M. tuberculosis isolates circulating in Iran and to analyze the relationship between genotype and drug resistance. A total of 291 M. tuberculosis isolates collected from TB patients were genotyped by spoligotyping. Drug susceptibility testing was performed using proportion method. Spoligotyping resulted in 75 distinct patterns. 86.2% of isolates were grouped in 35 clusters while the remaining isolates were unique. Ural was found to be the most predominant lineage (34.3%) followed by Central Asian strain (CAS) (24%), T (18.2%), Manu2 (7.5%) and Latin American-Mediterranean (LAM) (6.1%). The five largest clusters were Ural/Spoligotype International Type (SIT)127 (15.8%), CAS1/SIT26 (9.2%), T1/SIT53 (6.1%), T1/SIT284 (5.4%), and CAS1/SIT25 (4.4%). About 5% of isolates had multidrug resistance (MDR) and 10% had other resistance. MDR was significantly associated with Beijing strains, but not with Ural family. This study highlights dominance of Ural, CAS, and T families in Iran. Biogeographic specificity of CAS and T families to border provinces of Iran including Sistan-Baluchestan and Kermanshah, respectively, suggested that this family strains might be transmitted from these regions to other provinces of the country.
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