Evidence map›Paper›PMID 24311369›Full record

ArticleAngewandte Chemie (International ed. in English)2014

Lactose as a "Trojan horse" for quantum dot cell transport.

David Benito-Alifonso, Shirley Tremel, Bo Hou, Harriet Lockyear, Judith Mantell, David J Fermin, Paul Verkade, Monica Berry, M Carmen Galan

Open access · bronzeAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 73 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

David Benito-AlifonsoSchool of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS (UK).
Shirley Tremel
Bo Hou
Harriet Lockyear
Judith Mantell
David J Fermin
Paul Verkade
Monica Berry
M Carmen Galan
University of Bristol · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of glycan-coated quantum dots were prepared to probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial cells. We show that glycan density mostly impacts on cell toxicity, whereas glycan type affects the cell uptake and intracellular localization. Moreover, we show that lactose can act as a "Trojan horse" on bi-functionalized QDs to help intracellular delivery of other non-internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway.

Indexed as

Cell Line, TransformedCell SurvivalHeLa CellsHumansLactoseMicroscopy, ConfocalPolysaccharidesQuantum DotsLactosePolysaccharidesglycansintracellular localizationmultivalencynanoparticlesquantum dots

Identifiers

PMID24311369
PMCPMC4227560
OpenAlexW2108522607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.