ArticleLa Radiologia medica2014
In vivo imaging of T cells loaded with gold nanoparticles: a pilot study.
Article in La Radiologia medica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 14 citations in OpenAlex.
- Feasibility of Monitoring Tumor Response by Tracking Nanoparticle-Labelled T Cells Using X-ray Fluorescence Imaging-A Numerical Study.International journal of molecular sciences · 2021Article
- Immune cell labelling and tracking: implications for adoptive cell transfer therapies.EJNMMI radiopharmacy and chemistry · 2021Review
- Positron emission tomography and nanotechnology: A dynamic duo for cancer theranostics.Advanced drug delivery reviews · 2017Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMalignant tumours develop strategies to avoid immune recognition and elimination by T cells, even in individuals with a fully functioning immune system. To explore the treatment approach of adoptive immunotherapy, we exploited T cells loaded with radiolabelled gold nanoparticles (AuNPs) to track T cells in vivo. MATERIALS AND
methodsSurface-modified AuNPs were radiolabelled with (111)In or (64)Cu. They were then transferred into T cells via electroporation. To evaluate the effectiveness of this process, T cells loaded with (111)In-radiolabelled AuNPs were injected directly into the right lung of nude mice for in vivo imaging by micro-SPECT/CT. T cells loaded with (64)Cu-radiolabelled AuNPs were then injected into the tail vein of nude mice and imaged by micro-PET/CT.
resultsHigh uptake signals were observed in the right lung following the direct injection of T cells containing (111)In-labelled AuNPs. Imaging showed a marked difference in the dynamic biodistribution of T cells containing (64)Cu-labelled AuNPs when compared with (64)Cu-labelled AuNPs alone.
conclusionsThis study demonstrated the feasibility of the in vivo imaging of T cells loaded with radiolabelled AuNPs.
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