Evidence map›Paper›PMID 24310737›Full record

Trial reportScientific reports2013

Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans.

Nadine Striepens, Keith M Kendrick, Vanessa Hanking, Rainer Landgraf, Ullrich Wüllner, Wolfgang Maier, René Hurlemann

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03863288 (Dose-Response Relationship and Pharmacokinetics of Intranasal Oxytocin on Neural Impact in Youth With High Levels of Irritability), which is not on this map. Cited by 226 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
226citing papers in PubMed, 5 pooled it
50.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03863288 phase1 / phase2terminatednot on this mapstarted 2022, after this paper: background citation

Dose-Response Relationship and Pharmacokinetics of Intranasal Oxytocin on Neural Impact in Youth With High Levels of Irritability

TypeinterventionalSponsorUniversity of NebraskaRan2022 to 2024Enrolled60ConditionsIrritable MoodArmsFunctional MRI (fMRI), Oxytocin Intranasal Spray 8 International Unit (8IU), Oxytocin intranasal spray 24 International Unit (24IU), Oxytocin intranasal spray 48 International Unit (48IU), Oxytocin intranasal spray 80 International Unit (80IU)
3 · Its place in the literature

Who cites it

226 citing papers in PubMed, 5 syntheses or guidelines pooled it, 453 citations in OpenAlex.

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  14. Divergent effects of oxytocin on "mind-reading" in healthy males.Cognitive, affective & behavioral neuroscience · 2022
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166 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Nadine Striepens1] Department of Psychiatry, University of Bonn, 53105 Bonn, Germany [2] Division of Medical Psychology, University of Bonn, 53105 Bonn, Germany.
Keith M Kendrick
Vanessa Hanking
Rainer Landgraf
Ullrich Wüllner
Wolfgang Maier
René Hurlemann
University of Bonn · DEMax Planck Institute of Psychiatry · DEUniversity of Electronic Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There has been an unprecedented interest in the modulatory effects of intranasal oxytocin on human social cognition and behaviour, however as yet no study has actually demonstrated that this modality of administration increases concentrations of the peptide in the brain as well as blood in humans. Here using combined blood and cerebrospinal fluid (CSF) sampling in subjects receiving either 24 IU of oxytocin (n = 11) or placebo (n = 4) we have shown that oxytocin levels significantly increased in both plasma and CSF. However, whereas oxytocin plasma concentrations peaked at 15 min after intranasal administration and decreased after 75 min, CSF concentrations took up to 75 min to reach a significant level. Moreover, there was no correlation (r = <0.10) between oxytocin plasma and CSF concentrations. Together, these data provide crucial insights into the plasma and CSF kinetics of intranasally administered oxytocin.

Indexed as

Administration, IntranasalAdultDrug MonitoringHealthy VolunteersHumansMaleMiddle AgedNeuropsychological TestsOxytocinRadioimmunoassayTime FactorsYoung AdultOxytocin

Identifiers

PMID24310737
PMCPMC3853684
OpenAlexW2115046242

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.