ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Detection and genotype analysis of human papillomavirus in non-small cell lung cancer patients.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- HPV and lung cancer: A systematic review and meta-analysis.Cancer reports (Hoboken, N.J.) · 2021Pooled it
- Human papillomavirus and lung cancer: an overview and a meta-analysis.Journal of cancer research and clinical oncology · 2019Pooled it
- High-risk human papillomavirus infection and immunohistochemical expression patterns of p16 and Rb in primary and metastatic squamous cell carcinoma of the lung.Virchows Archiv : an international journal of pathology · 2026Article
- Association Between Human Papillomavirus and Thymic Cancer: A Population-Based Cohort Study.Cancer management and research · 2025Article
- HPV and Lung Cancer: A Systematic Review.Cancers · 2024Review
- Human Papillomavirus Is Rare and Does Not Correlate with p16Medicina (Kaunas, Lithuania) · 2024Article
- Review
- Possible Oncogenic Viruses Associated with Lung Cancer.OncoTargets and therapy · 2020Review
- Human papillomavirus is not associated to non-small cell lung cancer: data from a prospective cross-sectional study.Infectious agents and cancer · 2019Article
- The Association between Human Papillomavirus Infection and Smoking, Age, Gender in Lung Cancer Patients: A Meta-Analysis.Iranian journal of public health · 2019Review
- The association between human papillomavirus presence and epidermal growth factor receptor mutations in Asian patients with non-small cell lung cancer.Translational lung cancer research · 2018Article
- miR-185 and miR-29a are similarly expressed in the bronchoalveolar lavage cells in IPF and lung cancer but common targets DNMT1 and COL1A1 show disease specific patterns.Molecular medicine reports · 2018Article
- Individual and combined effect ofOncotarget · 2018Article
- The association between human papillomavirus infection and lung cancer: a system review and meta-analysis.Oncotarget · 2017Article
- Overexpression of Human Papillomavirus Type 16 Oncoproteins Enhances Epithelial-Mesenchymal Transition via STAT3 Signaling Pathway in Non-Small Cell Lung Cancer Cells.Oncology research · 2017Article
- Risk for molecular contamination of tissue samples evaluated for targeted anti-cancer therapy.PloS one · 2017Article
- Human papillomavirus and lung cancinogenesis: an overview.Journal of cancer research and clinical oncology · 2016Review
- Association between human papillomavirus andOncology letters · 2016Article
- Cystatin E/M Suppresses Tumor Cell Growth through Cytoplasmic Retention of NF-κB.Molecular and cellular biology · 2016Article
- Effect of FHIT loss and p53 mutation on HPV-infected lung carcinoma development.Oncology letters · 2015Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the role of human papillomavirus (HPV) in the development of uterine cervical cancer is well established, the role of HPV in lung carcinogenesis remains controversial. The detection rates of HPV DNA are subject to a wide variation from 0 to 100%. This is partly influenced by the detection techniques employed. To elucidate the impact of HPV infection on lung parenchyma, we analyzed 100 non-small cell lung cancer (NSCLC) specimens (39 squamous cell carcinomas, 50 adenocarcinomas, 5 samples with characteristics of both squamous cell and adenocarcinoma, 5 undifferentiated and 1 large cell carcinoma) from the region of Crete, Greece. Sixteen non-cancerous samples served as the negative controls. DNA was extracted from 100 paraffin-embedded tissue sections obtained from NSCLC patients. The specimens were examined for the detection of HPV DNA by Real-Time PCR using GP5+/GP6+ primers. Furthermore, the HPV-positive samples were subjected to genotyping. In contrast to the absence of viral genomes in the control samples, HPV DNA was detected in 19 NSCLC specimens (19%). In particular, 4 squamous cell carcinomas, 12 adenocarcinomas, 1 sample with characteristics of both squamous cell and adenocarcinoma, and 2 undifferentiated samples were HPV-positive. The distribution of HPV genotypes was as follows: HPV 16: eight cases (42.1%); HPV 11: three cases (15.8%); HPV 6: one case (5.2%); HPV 59: one case (5.2%); HPV 33: two cases (10.5%); HPV 31: two cases (10.5%) and HPV 18: two cases (10.5%). The presence of HPV in the tumor samples provides evidence of the potential role of HPV in NSCLC and strongly argues for additional research on this issue.
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