Trial reportJournal of perinatology : official journal of the California Perinatal Association2014
Frequency-modulated orocutaneous stimulation promotes non-nutritive suck development in preterm infants with respiratory distress syndrome or chronic lung disease.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Effects of trigeminal neurostimulation on heart rate variability: comparing cutaneous (Tragus) and tongue (Antero-Dorsal mucosa) stimulation.BMC oral health · 2024Trial
- Patterned frequency-modulated oral stimulation in preterm infants: A multicenter randomized controlled trial.PloS one · 2019Trial
- Amplitude-integrated EEG and range-EEG modulation associated with pneumatic orocutaneous stimulation in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2014Trial
- Longitudinal Changes in Aerodigestive Responses to Varying Nipple Properties in Infant Pigs.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025Article
- Non-Nutritive Suck Parameters Measurements Using a Custom Pressure Transducer System.Journal of visualized experiments : JoVE · 2024Article
- Impact of volume and rate of milk delivery on coordination of respiration and swallowing in infant pigs.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2023Article
- Nipple properties affect sensorimotor integration during bottle feeding in an infant pig model.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2023Article
- Oral stimulation for promoting oral feeding in preterm infants.The Cochrane database of systematic reviews · 2023Review
- The effect of stiffness and hole size on nipple compression in infant suckling.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2023Article
- Oro-Motor Intervention Protocol to Improve Sucking Behavior among Neonates with Immature Sucking: An Experimental Protocol.International journal of surgery protocols · 2021Article
- Does birth weight affect neonatal body weight, growth, and physiology in an animal model?PloS one · 2021Article
- Sucking versus swallowing coordination, integration, and performance in preterm and term infants.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Reduced Coordination of Hyolaryngeal Elevation and Bolus Movement in a Pig Model of Preterm Infant Swallowing.Dysphagia · 2020Article
- Preterm Birth Impacts the Timing and Excursion of Oropharyngeal Structures during Infant Feeding.Integrative organismal biology (Oxford, England) · 2020Article
- Automatic Nonnutritive Suck Waveform Discrimination and Feature Extraction in Preterm Infants.Computational and mathematical methods in medicine · 2019Article
- Preterm Neurodevelopmental Outcomes Following Orosensory Entrainment Intervention.Journal of neonatal nursing : JNN · 2018Article
- Somatosensory Modulation of Salivary Gene Expression and Oral Feeding in Preterm Infants: Randomized Controlled Trial.JMIR research protocols · 2017Article
- Patterned auditory stimulation and suck dynamics in full-term infants.Acta paediatrica (Oslo, Norway : 1992) · 2017Article
- Oral stimulation for promoting oral feeding in preterm infants.The Cochrane database of systematic reviews · 2016Review
- Effects of pacifier and taste on swallowing, esophageal motility, transit, and respiratory rhythm in human neonates.Neurogastroenterology and motility · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveFor the premature infant, extrauterine life is a pathological condition, which greatly amplifies the challenges to the brain in establishing functional oromotor behaviors. The extent to which suck can be entrained using a synthetically patterned orocutaneous input to promote its development in preterm infants who manifest chronic lung disease (CLD) is unknown. The objective of this study was to evaluate the effects of a frequency-modulated (FM) orocutaneous pulse train delivered through a pneumatically charged pacifier capable of enhancing non-nutritive suck (NNS) activity in tube-fed premature infants. STUDY
designA randomized trial to evaluate the efficacy of pneumatic orocutaneous stimulation 3 × per day on NNS development and length of stay (LOS) in the neonatal intensive care unit among 160 newborn infants distributed among three sub-populations, including healthy preterm infants, respiratory distress syndrome (RDS) and CLD. Study infants received a regimen of orocutaneous pulse trains through a PULSED pressurized silicone pacifier or a SHAM control (blind pacifier) during gavage feeds for up to 10 days.
resultMixed modeling, adjusted for the infant's gender, gestational age, postmenstrual age and birth weight, was used to handle interdependency among repeated measures within subjects. A significant main effect for stimulation mode (SHAM pacifier vs PULSED orosensory) was found among preterm infants for NNS bursts per min (P=0.003), NNS events per min (P=0.033) and for total oral compressions per min (NNS+nonNNS) (P=0.016). Pairwise comparison of adjusted means using Bonferroni adjustment indicated RDS and CLD infants showed the most significant gains on these NNS performance indices. CLD infants in the treatment group showed significantly shorter LOS by an average of 2.5 days.
conclusionFM PULSED orocutaneous pulse train stimuli delivered through a silicone pacifier are effective in facilitating NNS burst development in tube-fed RDS and CLD preterm infants, with an added benefit of reduced LOS for CLD infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.