Evidence map›Paper›PMID 24310443›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2014

Amplitude-integrated EEG and range-EEG modulation associated with pneumatic orocutaneous stimulation in preterm infants.

S M Barlow, P Jegatheesan, S Weiss, B Govindaswami, J Wang, J Lee, A Oder, D Song

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

S M BarlowSPLH-Neuroscience and Bioengineering, University of Kansas, Lawrence, KS, USA.
P JegatheesanSanta Clara Valley Medical Center, Neonatology, San Jose, CA, USA.
S WeissSanta Clara Valley Medical Center, Neonatology, San Jose, CA, USA.
B GovindaswamiSanta Clara Valley Medical Center, Neonatology, San Jose, CA, USA.
J WangSPLH-Neuroscience and Bioengineering, University of Kansas, Lawrence, KS, USA.
J LeeCenter for Research Methods and Data Analysis, University of Kansas, Lawrence, KS, USA.
A OderSPLH-Neuroscience and Bioengineering, University of Kansas, Lawrence, KS, USA.
D SongSanta Clara Valley Medical Center, Neonatology, San Jose, CA, USA.
Santa Clara Valley Medical Center · USUniversity of Kansas · US

Funding

Research Design and Analysis Core (RDAC)P30HD002528 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI FOWLER, STEPHEN CLETIUS · 1985 to 2015
$22.1M
Sensorimotor Control of the Human Orofacial SystemR01DC003311 · NIDCD · UNIVERSITY OF NEBRASKA LINCOLN · PI BARLOW, STEVEN M · 2002 to 2012
$4.7M
NICHD NIH HHS P30 HD002528NICHD NIH HHS P30 HD02528NIDCD NIH HHS R01 DC003311
6 · The paper itself

Abstract

objectiveControlled somatosensory stimulation strategies have demonstrated merit in developing oral feeding skills in premature infants who lack a functional suck, however, the effects of orosensory entrainment stimulation on electrocortical dynamics is unknown. The objective of the study was to determine the effects of servo-controlled pneumatic orocutaneous stimulation presented during gavage feedings on the modulation of amplitude-integrated electroencephalogram (aEEG) and range electroencephalogram (rEEG) activity. STUDY

designTwo-channel EEG recordings were collected during 180 sessions that included orocutaneous stimulation and non-stimulation epochs among 22 preterm infants (mean gestational age=28.56 weeks) who were randomized to treatment and control 'sham' conditions. The study was initiated at around 32 weeks post-menstrual age. The raw EEG was transformed into aEEG margins, and rEEG amplitude bands measured at 1-min intervals and subjected to a mixed models statistical analysis.

resultMultiple significant effects were observed in the processed EEG during and immediately following 3-min periods of orocutaneous stimulation, including modulation of the upper and lower margins of the aEEG, and a reorganization of rEEG with an apparent shift from amplitude bands D and E to band C throughout the 23-min recording period that followed the first stimulus block when compared with the sham condition. Cortical asymmetry also was apparent in both EEG measures.

conclusionOrocutaneous stimulation represents a salient trigeminal input, which has both short- and long-term effects in modulating electrocortical activity, and thus is hypothesized to represent a form of neural adaptation or plasticity that may benefit the preterm infant during this critical period of brain maturation.

Indexed as

ElectroencephalographyPacifiersPhysical StimulationFemaleHumansInfant, NewbornInfant, PrematureMaleMouthSignal Processing, Computer-Assisted

Identifiers

PMID24310443
PMCPMC3943746
OpenAlexW2020460881

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.