ArticleEuropean journal of nuclear medicine and molecular imaging2014
Association between left ventricular regional sympathetic denervation and mechanical dyssynchrony in phase analysis: a cardiac CZT study.
Article in European journal of nuclear medicine and molecular imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Relationships between cardiac innervation/perfusion imbalance and ventricular arrhythmias: impact on invasive electrophysiological parameters and ablation procedures.European journal of nuclear medicine and molecular imaging · 2016Trial
- Coronary physiology in the cath lab: is "virtual FFR" ready for the prime time?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Performance evaluation of a novel multi-pinhole collimator on triple-NaI-detector SPECT/CT for dedicated myocardial imaging.EJNMMI physics · 2023Article
- The value of cardiac sympathetic activity and mechanical dyssynchrony as cardiac resynchronization therapy response predictors: comparison between patients with ischemic and non-ischemic heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Evaluation of dyssynchrony with nuclear cardiac imaging: New evidence for an old parameter.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Cardiac sympathetic dysfunction in left ventricular hypertrophy caused by arterial hypertension and degenerative aortic stenosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- A Left Ventricular Mechanical Dyssynchrony-Based Nomogram for Predicting Major Adverse Cardiac Events Risk in Patients With Ischemia and No Obstructive Coronary Artery Disease.Frontiers in cardiovascular medicine · 2022Article
- Cardio-pulmonary involvement in pulmonary arterial hypertension: A perfusion and innervation scintigraphic evaluation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Interactions between myocardial sympathetic denervation and left ventricular mechanical dyssynchrony: A CZT analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- First assessment of simultaneous dual isotope (Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Relationships between left ventricular sympathetic innervation and diastolic dysfunction: the role of myocardial innervation/perfusion mismatch.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Evaluation of myocardial sympathetic innervation in the 21st century: Is there a role for planarJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Imaging the heart's brain: Simultaneous innervation/perfusion analysis in the era of new CZT cameras.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Acrolein Inhalation Alters Myocardial Synchrony and Performance at and Below Exposure Concentrations that Cause Ventilatory Responses.Cardiovascular toxicology · 2017Article
- Left ventricular function assessment usingEJNMMI physics · 2016Article
- Determinants of left ventricular mechanical dyssynchrony in patients submitted to myocardial perfusion imaging: A cardiac CZT study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- First determination of the heart-to-mediastinum ratio using cardiac dual isotope (¹²³I-MIBG/⁹⁹mTc-tetrofosmin) CZT imaging in patients with heart failure: the ADRECARD study.European journal of nuclear medicine and molecular imaging · 2015Article
- Alterations of left ventricular deformation and cardiac sympathetic derangement in patients with systolic heart failure: a 3D speckle tracking echocardiography and cardiac ¹²³I-MIBG study.European journal of nuclear medicine and molecular imaging · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the relationships among myocardial sympathetic innervation, perfusion and mechanical synchronicity assessed with cardiac cadmium-zinc-telluride (CZT) scintigraphy.
methodsA group of 29 patients underwent an evaluation of myocardial perfusion with (99m)Tc-tetrofosmin CZT scintigraphy and adrenergic innervation with (123)I-metaiodobenzylguanidine (MIBG) CZT scintigraphy. The summed rest score (SRS), motion score (SMS) and thickening score (STS), as well as the summed (123)I-MIBG defect score (SS-MIBG), were determined. Regional tracer uptake for both (99m)Tc-tetrofosmin and (123)I-MIBG was also calculated. Finally, the presence of significant myocardial mechanical dyssynchrony was evaluated in phase analysis on gated CZT images and the region of latest mechanical activation identified.
resultsSignificant mechanical dyssynchrony was present in 17 patients (59 %) and associated with higher SRS (P = 0.030), SMS (P < 0.001), STS (P = 0.003) and early SS-MIBG (P = 0.037) as well as greater impairments in left ventricular ejection fraction (P < 0.001) and end-diastolic volume (P < 0.001). In multivariate analysis a higher end-diastolic volume remained the only predictor of mechanical dyssynchrony (P = 0.047). Interestingly, while in the whole population regional myocardial perfusion and adrenergic activity were strongly correlated (R = 0.68), in patients with mechanical dyssynchrony the region of latest mechanical activation was predicted only by greater impairment in regional (123)I-MIBG uptake (P = 0.012) that overwhelmed the effect of depressed regional perfusion.
conclusionLeft ventricular mechanical dyssynchrony is associated with greater depression in contractile function and greater impairments in regional myocardial perfusion and sympathetic activity. In patients with dyssynchrony, the region of latest mechanical activation is characterized by a significantly altered adrenergic tone.
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