ArticleCancers2011
Tumor acidity as evolutionary spite.
Article in Cancers, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed.
- Single-Cell RNA Sequencing Reveals the Heterogeneity and Microenvironment of Temporal Bone Squamous Cell Carcinoma.Clinical and experimental otorhinolaryngology · 2026Article
- Polyglycerol-Grafted Graphene Oxide with pH-Responsive Charge-Convertible Surface to Dynamically Control the Nanobiointeractions for Enhanced in Vivo Tumor Internalization.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Compound K-enriched Korean red ginseng prevents lung cancer progression by targeting cancer cells and fibroblasts.Journal of ginseng research · 2025Article
- Tumor alkalization therapy: misconception or good therapeutics perspective? - the case of malignant ascites.Frontiers in oncology · 2024Article
- Tumor Organoid and Spheroid Models for Cervical Cancer.Cancers · 2023Review
- Tumor-Infiltrating Immune Cell Landscapes in the Lymph Node Metastasis of Papillary Thyroid Cancer.Current oncology (Toronto, Ont.) · 2023Article
- Hybrid computational models of multicellular tumour growth considering glucose metabolism.Computational and structural biotechnology journal · 2023Review
- Review
- Review
- Human monocytes differentiate into tumor-associated macrophages upon SKOV3 cells coculture and/or lysophosphatidic acid stimulation.Journal of inflammation (London, England) · 2022Article
- GLUT1 production in cancer cells: a tragedy of the commons.NPJ systems biology and applications · 2022Article
- Cell-in-Cell Events in Oral Squamous Cell Carcinoma.Frontiers in oncology · 2022Review
- Of mitochondrion and COVID-19.Journal of enzyme inhibition and medicinal chemistry · 2021Review
- Pharmaceutical Aspects of Nanocarriers for Smart Anticancer Therapy.Pharmaceutics · 2021Review
- A comprehensive analysis of tumor microenvironment-related genes in colon cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021Article
- Metabolic Acidosis in Leukemia.Cureus · 2021Review
- Metabolic Shifts as the Hallmark of Most Common Diseases: The Quest for the Underlying Unity.International journal of molecular sciences · 2021Article
- Eccentric Cycling Training Improves Erythrocyte Antioxidant and Oxygen Releasing Capacity Associated with Enhanced Anaerobic Glycolysis and Intracellular Acidosis.Antioxidants (Basel, Switzerland) · 2021Article
- Acetic Acid and Iodine Staining for Determining Malignancy in Solid Tumors.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Multifunctional and stimuli-responsive nanocarriers for targeted therapeutic delivery.Expert opinion on drug delivery · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most cancer cells shift their metabolic pathway from a metabolism reflecting the Pasteur-effect into one reflecting the Warburg-effect. This shift creates an acidic microenvironment around the tumor and becomes the driving force for a positive carcinogenesis feedback loop. As a consequence of tumor acidity, the tumor microenvironment encourages a selection of certain cell phenotypes that are able to survive in this caustic environment to the detriment of other cell types. This selection can be described by a process which can be modeled upon spite: the tumor cells reduce their own fitness by making an acidic environment, but this reduces the fitness of their competitors to an even greater extent. Moreover, the environment is an important dimension that further drives this spite process. Thus, diminishing the selective environment most probably interferes with the spite process. Such interference has been recently utilized in cancer treatment.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.