ReviewReproduction (Cambridge, England)2014
Persistent environmental pollutants and couple fecundity: an overview.
Review in Reproduction (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Beetroot, watermelon and ginger juice supplementation may increase the clinical outcomes of Intracytoplasmic Sperm Injection cycles.JBRA assisted reproduction · 2023Trial
- Long term exposure to road traffic noise and air pollution and risk of infertility in men and women: nationwide Danish cohort study.BMJ (Clinical research ed.) · 2024Article
- Environmental exposure to industrial air pollution is associated with decreased male fertility.Fertility and sterility · 2023Article
- Maternal fluoride exposure, fertility and birth outcomes: The MIREC cohort.Environmental advances · 2022Article
- REPRODUCTIVE TOXICOLOGY: Endocrine disruption and reproductive disorders: impacts on sexually dimorphic neuroendocrine pathways.Reproduction (Cambridge, England) · 2021Review
- Environmental Factors Involved in Maternal Morbidity and Mortality.Journal of women's health (2002) · 2021Article
- Environmental risk factors for endometriosis: A critical evaluation of studies and recommendations from the epidemiologic perspective.Current epidemiology reports · 2020Article
- Mining leachate contamination and subfecundity among women living near the USA-Mexico border.Environmental geochemistry and health · 2019Article
- Seafood Intake, Sexual Activity, and Time to Pregnancy.The Journal of clinical endocrinology and metabolism · 2018Article
- Time-varying cycle average and daily variation in ambient air pollution and fecundability.Human reproduction (Oxford, England) · 2018Article
- Post-Disaster Fertility: Hurricane Katrina and the Changing Racial Composition of New Orleans.Population and environment · 2017Article
- Exposure to endocrine disruptors during adulthood: consequences for female fertility.The Journal of endocrinology · 2017Review
- Effects of perfluorinated chemicals on thyroid function, markers of ovarian reserve, and natural fertility.Reproductive toxicology (Elmsford, N.Y.) · 2017Article
- Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: Translating lessons from murine models.Reproductive toxicology (Elmsford, N.Y.) · 2017Review
- Effects of maternal smoking on offspring reproductive outcomes: an intergenerational study in the North East of Scotland.Human reproduction open · 2017Article
- Time-to-Pregnancy Associated With Couples' Use of Tobacco Products.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Observational
- The gut microbiota: a major player in the toxicity of environmental pollutants?NPJ biofilms and microbiomes · 2016Review
- Urinary Phytoestrogens Are Associated with Subtle Indicators of Semen Quality among Male Partners of Couples Desiring Pregnancy.The Journal of nutrition · 2015Article
- Oestrogen action and male fertility: experimental and clinical findings.Cellular and molecular life sciences : CMLS · 2015Review
- Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Speculation has arisen that human fecundity may be declining, possibly a function of exposure to persistent environmental chemicals that resist degradation resulting in various pathways for human exposure. In contrast to considerable animal evidence suggesting adverse effects of such chemicals on reproduction, limited human research has been undertaken. To date, available data stem largely from ten unique study cohorts that have quantified individual chemical exposures in relation to time-to-pregnancy (TTP), which is a measure of couple fecundity. Diminished fecundability odds ratios indicative of longer TTP were observed in all but two studies, although not all findings achieved statistical significance. Persistent chemicals associated with reduced couple fecundity as measured by a longer TTP included βHCH, cadmium, lead, mercury, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene, TCCD dioxin, and select polybrominated diethers, polychlorinated biphenyls, and perfluorochemicals. Important methodologic limitations need to be considered in weighing the evidence: i) reliance on pregnant women, which may exclude women with the highest exposures if related to the inability to conceive; ii) retrospectively reported TTP, which may be associated with bidirectional reporting errors; and iii) limited attention to male partners or couples' exposures. While current evidence is not inconsistent with animal evidence, concerted efforts to address lingering data gaps should include novel strategies for recruiting couples, the longitudinal measurement of TTP, and the continued enrollment of couples across successive pregnancies. This latter strategy will provide a more complete understanding of the toxicokinetics of chemicals during sensitive windows and their implications for fecundity and its related impairments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.