ArticleNature protocols2014
Structural and functional analysis of single neurons to correlate synaptic connectivity with grooming behavior.
Article in Nature protocols, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Mechanosensory and command contributions to the Drosophila grooming sequence.Current biology : CB · 2024Article
- Somatotopic organization among parallel sensory pathways that promote a grooming sequence ineLife · 2024Article
- Somatotopic organization among parallel sensory pathways that promote a grooming sequence inbioRxiv : the preprint server for biology · 2023Article
- Mechanosensory and command contributions to thebioRxiv : the preprint server for biology · 2023Article
- Article
- FGF receptors are required for proper axonal branch targeting in Drosophila.Molecular brain · 2019Article
- Article
- Quantification of Drosophila Grooming Behavior.Journal of visualized experiments : JoVE · 2017Article
- Neural circuitry coordinating male copulation.eLife · 2016Article
- A Defensive Kicking Behavior in Response to Mechanical Stimuli Mediated by Drosophila Wing Margin Bristles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- A suppression hierarchy among competing motor programs drives sequential grooming in Drosophila.eLife · 2014Article
- Hygienic grooming is induced by contact chemicals in Drosophila melanogaster.Frontiers in behavioral neuroscience · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We describe a protocol to image the complex axonal branching structure of identified mechanosensory neurons in Drosophila, combined with a behavioral assay to evaluate the functional output of the neuron. The stimulation of identified mechanosensory neurons in live animals produces a stereotyped grooming reflex. The mechanosensory axonal arbor within the CNS is subsequently labeled with a lipophilic fluorescent dye and imaged by fluorescence microscopy. The behavioral output can therefore be correlated to the axonal morphology of the stimulated neuron in the same animal. Combining this protocol with genetic analysis provides a powerful tool for identifying the roles of molecules involved in different aspects of hard-wired neural circuit formation underlying an innate behavior. From behavioral analysis to axonal imaging, the protocol takes 4 d.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.