ArticleThe Journal of cell biology1986
The tyrosine phosphorylation substrate p36 is developmentally regulated in embryonic avian limb and is induced in cell culture.
Article in The Journal of cell biology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- Architecture Is the Message: The role of extracellular matrix and 3-D structure in tissue-specific gene expression and breast cancer.The Pezcoller Foundation journal : news from the Pezcoller Foundation world · 2007Article
- The pattern of plant annexin gene expression.The Biochemical journal · 1992Article
- Expression of annexin VI (p68, 67 kDa-calelectrin) in normal human tissues: evidence for developmental regulation in B- and T-lymphocytes.Histochemistry · 1991Article
- The embryonic environment strongly attenuates v-src oncogenesis in mesenchymal and epithelial tissues, but not in endothelia.The Journal of cell biology · 1990Article
- Expression of annexins as a function of cellular growth state.The Journal of cell biology · 1990Article
- Enhanced expression of the protein kinase substrate p36 in human hepatocellular carcinoma.Molecular and cellular biology · 1990Article
- Synthesis of p36 and p35 is increased when U-937 cells differentiate in culture but expression is not inducible by glucocorticoids.Molecular and cellular biology · 1989Article
- pp60v-src tyrosine kinase is expressed and active in sarcoma-free avian embryos microinjected with Rous sarcoma virus.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- The calpactin light chain is tightly linked to the cytoskeletal form of calpactin I: studies using monoclonal antibodies to calpactin subunits.The Journal of cell biology · 1987Article
- Regulation of calpactin I phospholipid binding by calpactin I light-chain binding and phosphorylation by p60v-src.The Biochemical journal · 1987Article
- Annexin II tetramer: structure and function.Molecular and cellular biochemistryReview
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4 authors.
Funding
Abstract
The 36-kD protein-tyrosine kinase substrate p36 has been variously postulated to be involved in membrane-cytoskeletal interactions, membrane traffic, and the regulation of phospholipase A2, and its phosphorylation may play some role in malignant transformation by avian sarcoma viruses. Because embryonic tissues are resistant to transformation by avian sarcoma viruses, we have examined the expression of p36 in the developing avian embryonic limb. The level of p36 increased progressively from day 5 to day 14 of development. It was largely absent from day-5 mesenchyme, and was induced during the differentiation of mesenchymal cells into connective tissue and cartilage, but was not induced in differentiating muscle. In contrast, p36 was detected in ectodermal cells at all developmental stages examined. When day-5 limbs were dissociated and cultured, p36 was induced in all adherent cells, beginning at 2-4 h after plating, and reaching levels comparable to those observed with intact day-14 limb tissue within 48 h. The accumulation of p36 in culture was dependent on substratum adherence, suggesting that its stability is regulated by cell attachment or spreading. These findings are consistent with a structural or mechanical role for p36.
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