ArticleThe Journal of cell biology1986
Evidence for posttranscriptional regulation of the keratins expressed during hyperproliferation and malignant transformation in human epidermis.
Article in The Journal of cell biology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 163 citations in OpenAlex.
- Article
- Pathophysiology of pachyonychia congenita-associated palmoplantar keratoderma: new insights into skin epithelial homeostasis and avenues for treatment.The British journal of dermatology · 2020Review
- Article
- Human notochordal cell transcriptome unveils potential regulators of cell function in the developing intervertebral disc.Scientific reports · 2018Article
- Article
- A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies.Nature cell biology · 2014Article
- Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling.PloS one · 2012Article
- Modulation of gastrointestinal inflammation and colorectal tumorigenesis by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ).Drug discovery today. Disease mechanisms · 2011Article
- Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice.PloS one · 2010Article
- Cytokeratin expression during mouse embryonic and early postnatal mammary gland development.Histochemistry and cell biology · 2010Article
- Sorting out the functional role(s) of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) in cell proliferation and cancer.Biochimica et biophysica acta · 2009Review
- siRNA silencing of keratinocyte-specific GFP expression in a transgenic mouse skin model.Gene therapy · 2009Article
- ELR-negative CXC chemokine CXCL11 (IP-9/I-TAC) facilitates dermal and epidermal maturation during wound repair.The American journal of pathology · 2008Article
- HPV8 early genes modulate differentiation and cell cycle of primary human adult keratinocytes.Experimental dermatology · 2007Article
- Role of the Cldn6 cytoplasmic tail domain in membrane targeting and epidermal differentiation in vivo.Molecular and cellular biology · 2006Article
- Loss of keratin 6 (K6) proteins reveals a function for intermediate filaments during wound repair.The Journal of cell biology · 2003Article
- Introducing a null mutation in the mouse K6alpha and K6beta genes reveals their essential structural role in the oral mucosa.The Journal of cell biology · 2000Article
- The functional diversity of epidermal keratins revealed by the partial rescue of the keratin 14 null phenotype by keratin 16.The Journal of cell biology · 1999Article
- Regulation of keratin and integrin gene expression in cancer and drug resistance.Cytotechnology · 1998Article
- Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates.The Journal of cell biology · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keratin K6 is a protein that is expressed in human skin under conditions of hyperproliferation (e.g., wound-healing, psoriasis, and cell culture) and malignant transformation (e.g., squamous cell carcinomas). When induced, the appearance of K6 is rapid: if skin tissue is placed in radiolabeled culture medium, this protein can be detected within an hour. The regulation of K6 seems to be controlled partly by a posttranscriptional mechanism: At least two K6 genes are actively transcribed both in vivo, when the protein is not made, as well as in vitro, when abundant levels of the protein are expressed. Substantial levels of K6a and K6b RNAs can be detected in skin by Northern Blot analysis, and these RNAs are largely, if not fully translatable in vitro. In situ hybridizations reveal that the RNAs are distributed throughout the living layers of the epidermis. The rapid induction of K6 expression through a posttranscriptional regulatory mechanism suggests that this keratin may play an important role in designing a cytoskeletal architecture that is compatible with the hyperproliferative state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.