ArticleNature communications2013
miRNomes of haematopoietic stem cells and dendritic cells identify miR-30b as a regulator of Notch1.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
- Therapeutic effect of miR-30b-5p-loaded lentivirus on experimental autoimmune uveitis via inhibiting Notch signaling activation.Journal of translational medicine · 2025Article
- Epigenetic modulations of immune cells: from normal development to tumor progression.International journal of biological sciences · 2023Review
- MiR-30 Family: A Novel Avenue for Treating Bone and Joint Diseases?International journal of medical sciences · 2023Review
- miR-aculous new avenues for cancer immunotherapy.Frontiers in immunology · 2022Review
- A regulatory network of microRNAs confers lineage commitment during early developmental trajectories of B and T lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Single-cell Transcriptomes Reveal Characteristics of MicroRNAs in Gene Expression Noise Reduction.Genomics, proteomics & bioinformatics · 2021Article
- Down-Regulation of microRNA-30d Alleviates Intervertebral Disc Degeneration Through the Promotion of FOXO3 and Suppression of CXCL10.Calcified tissue international · 2021Article
- Porcine Reproductive and Respiratory Syndrome Virus Evades Antiviral Innate ImmunityFrontiers in microbiology · 2021Review
- MicroRNA-30a Modulates Type I Interferon Responses to Facilitate Coxsackievirus B3 ReplicationFrontiers in immunology · 2020Article
- Inducible degradation of lncRNA Sros1 promotes IFN-γ-mediated activation of innate immune responses by stabilizing Stat1 mRNA.Nature immunology · 2019Article
- Immune cells as targets for cardioprotection: new players and novel therapeutic opportunities.Cardiovascular research · 2019Review
- Mettl3-mediated mRNA mNature communications · 2019Article
- Expression of Serum microRNAs is Altered During Acute Graft-versus-Host Disease.Frontiers in immunology · 2017Article
- Endogenous and tumour-derived microRNAs regulate cross-presentation in dendritic cells and consequently cytotoxic T cell function.Cytotechnology · 2016Review
- Electrophoresis separation assisted G-quadruplex DNAzyme-based chemiluminescence signal amplification strategy on a microchip platform for highly sensitive detection of microRNA.Chemical communications (Cambridge, England) · 2016Article
- miR-24, miR-30b and miR-142-3p interfere with antigen processing and presentation by primary macrophages and dendritic cells.Scientific reports · 2016Article
- DNA-PK-mediated phosphorylation of EZH2 regulates the DNA damage-induced apoptosis to maintain T-cell genomic integrity.Cell death & disease · 2016Article
- TCF4-Targeting miR-124 is Differentially Expressed amongst Dendritic Cell Subsets.Immune network · 2016Article
- Influence of miR-30b regulating humoral immune response by genetic difference.Immunologic research · 2016Article
- Reciprocal control of miR-197 and IL-6/STAT3 pathway reveals miR-197 as potential therapeutic target for hepatocellular carcinoma.Oncoimmunology · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells (DCs) are critical to initiate the immune response and maintain tolerance, depending on different status and subsets. The expression profiles of microRNAs (miRNAs) in various DC subsets and haematopoietic stem cells (HSCs), which generate DCs, remain to be fully identified. Here we examine miRNomes of mouse bone marrow HSCs, immature DCs, mature DCs and IL-10/NO-producing regulatory DCs by deep sequencing. We identify numerous stage-specific miRNAs and histone modification in HSCs and DCs at different differentiation stages. miR-30b, significantly upregulated via a TGF-beta/Smad3-mediated epigenetic pathway in regulatory DCs, can target Notch1 to promote IL-10 and NO production, suggesting that miR-30b is a negative regulator of immune response. We also identify miRNomes of in vivo counterparts of mature DCs and regulatory DCs and systematically compare them with DCs cultured in vitro. These results provide a resource for studying roles of miRNAs in stem cell biology, development and functional regulation of DC subsets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.