Evidence map›Paper›PMID 24309436›Full record

ReviewDental materials : official publication of the Academy of Dental Materials2014

Dentin biomodification: strategies, renewable resources and clinical applications.

Ana K Bedran-Russo, Guido F Pauli, Shao-Nong Chen, James McAlpine, Carina S Castellan, Rasika S Phansalkar, Thaiane R Aguiar, Cristina M P Vidal, José G Napotilano, Joo-Won Nam and 1 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dental materials : official publication of the Academy of Dental Materials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 3 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 3 syntheses or guidelines pooled it, 297 citations in OpenAlex.

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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Ana K Bedran-RussoDepartment of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: bedran@uic.edu.
Guido F PauliDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
Shao-Nong ChenDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
James McAlpineDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
Carina S CastellanDepartment of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA; Department of Biochemistry and Dental Biomaterials, School of Dentistry, University of Sao Paulo, Sao Paulo, SP, Brazil.
Rasika S PhansalkarDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
Thaiane R AguiarDepartment of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA.
Cristina M P VidalDepartment of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA.
José G NapotilanoDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
Joo-Won NamDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
Ariene A LemeDepartment of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA.
University of Illinois Chicago · USUniversidade de São Paulo · BR

Funding

Biomodification of Dentin Matrix StructureR01DE021040 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BEDRAN-RUSSO, ANA KARINA B · 2011 to 2015
$2.1M
Stability of cross-linked dentin and its clinical applicationK08DE017740 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BEDRAN-RUSSO, ANA KARINA B · 2006 to 2010
$744k
NIDCR NIH HHS DE017740NIDCR NIH HHS DE017740-01S4NIDCR NIH HHS K08 DE017740NIDCR NIH HHS R01 DE021040NIDCR NIH HHS R01DE021040
6 · The paper itself

Abstract

objectivesThe biomodification of dentin is a biomimetic approach, mediated by bioactive agents, to enhance and reinforce the dentin by locally altering the biochemistry and biomechanical properties. This review provides an overview of key dentin matrix components, targeting effects of biomodification strategies, the chemistry of renewable natural sources, and current research on their potential clinical applications.

methodsThe PubMed database and collected literature were used as a resource for peer-reviewed articles to highlight the topics of dentin hierarchical structure, biomodification agents, and laboratorial investigations of their clinical applications. In addition, new data is presented on laboratorial methods for the standardization of proanthocyanidin-rich preparations as a renewable source of plant-derived biomodification agents.

resultsBiomodification agents can be categorized as physical methods and chemical agents. Synthetic and naturally occurring chemical strategies present distinctive mechanism of interaction with the tissue. Initially thought to be driven only by inter- or intra-molecular collagen induced non-enzymatic cross-linking, multiple interactions with other dentin components are fundamental for the long-term biomechanics and biostability of the tissue. Oligomeric proanthocyanidins show promising bioactivity, and their chemical complexity requires systematic evaluation of the active compounds to produce a fully standardized intervention material from renewable resource, prior to their detailed clinical evaluation. SIGNIFICANCE: Understanding the hierarchical structure of dentin and the targeting effect of the bioactive compounds will establish their use in both dentin-biomaterials interface and caries management.

Indexed as

DentinExtracellular MatrixHumansProanthocyanidinsProanthocyanidinsBiomaterialsCarbodiimideCollagen cross-linkingDental cariesDentinProanthocyanidinsResin–dentin interfacesSurface biomodification

Identifiers

PMID24309436
PMCPMC3972923
OpenAlexW2167877382

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.