ArticleVeterinary microbiology2014
Pathogenesis of GIII.2 bovine norovirus, CV186-OH/00/US strain in gnotobiotic calves.
Article in Veterinary microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Clinical and Epidemiological Features of Calicivirus Infections in Cattle.Animals : an open access journal from MDPI · 2026Review
- Molecular characteristics of bovine norovirus and nebovirus in Swedish dairy herds.Acta veterinaria Scandinavica · 2025Article
- Immunogenicity of Virus-like Particles Based on VP1 Protein of Bovine Norovirus.Veterinary sciences · 2025Article
- A multiplex real-time fluorescence-based quantitative PCR assay for calf diarrhea viruses.Frontiers in microbiology · 2023Article
- Metagenomic analysis reveals presence of different animal viruses in commercial fetal bovine serum and trypsin.Zoological research · 2022Article
- Literature Review: Coinfection in Young Ruminant Livestock-Pathogens (Basel, Switzerland) · 2022Review
- Prevalence and complete genome of bovine norovirus with novel VP1 genotype in calves in China.Scientific reports · 2019Article
- Animals as Reservoir for Human Norovirus.Viruses · 2019Review
- Free-Chlorine Disinfection as a Selection Pressure on Norovirus.Applied and environmental microbiology · 2018Article
- Phylogeny of bovine norovirus in Egypt based on VP2 gene.International journal of veterinary science and medicine · 2018Article
- First detection of Nebovirus and Norovirus from cattle in China.Archives of virology · 2018Article
- Article
- Calves are susceptible to infection with the newly emerged porcine deltacoronavirus, but not with the swine enteric alphacoronavirus, porcine epidemic diarrhea virus.Archives of virology · 2017Article
- Experimental infection of gnotobiotic pigs with the cell-culture-adapted porcine deltacoronavirus strain OH-FD22.Archives of virology · 2016Article
- Molecular detection of bovine Noroviruses in Argentinean dairy calves: Circulation of a tentative new genotype.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Bovine noroviruses: A missing component of calf diarrhoea diagnosis.Veterinary journal (London, England : 1997) · 2016Review
- Enteric viral infections in lambs or kids.Veterinary microbiology · 2015Review
- Norovirus immunology: Of mice and mechanisms.European journal of immunology · 2015Review
- Norovirus vaccines and potential antinorovirus drugs: recent advances and future perspectives.Future virologyArticle
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5 authors.
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Abstract
The pathogenesis of GIII.2 bovine norovirus (BoNoV) is not well understood. Our study demonstrated persisting diarrhea and prolonged fecal shedding, but with a lack of significant intestinal lesions in gnotobiotic (Gn) calves infected with GIII.2 BoNoV, CV186-OH/00/US strain. Nine 4 to 7-day-old Angus/Jersey crossbred Gn calves were orally inoculated with 10.0-11.9 log10 genomic equivalents (GE)/calf of CV186-OH (n=7) or mock (n=2). Calves were euthanized at post-inoculation day (PID) 1 (n=1) when moderate to severe lethargy was observed and at PIDs 2-6 (n=4) after lethargy had subsided. Two calves were kept longer term (until PID 30) for monitoring fecal shedding patterns by TaqMan real-time RT-PCR (qRT-PCR). Most infected calves exhibited two clinical signs: (i) acute but persisting diarrhea and (ii) acute moderate to severe lethargy. The two infected calves, followed longer-term, had prolonged fecal viral RNA shedding [peak average titer of 11.8 (± 0.2) log10GE/ml] at least until PID 20. By qRT-PCR, 5 infected calves had low viral RNA titers in serum, ranging from 4.0 to 5.8 log10GE/ml, at PIDs 1-5, but not (<2.7 log10GE/ml) at PIDs 6-30. The latter observation coincided with the presence of serum IgG antibody to BoNoV at PIDs 8-30. Collectively, the GIII.2 BoNoV strain CV186-OH induced only mild enteropathogenicity, evident by the lack of significant intestinal lesions, but it led to persisting mild diarrhea and prolonged fecal virus shedding in Gn calves. The prolonged fecal shedding of GIII.2 BoNoV might partially explain how this virus is maintained as endemic infections in cattle.
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