ArticleJournal of the American Chemical Society2014
A concise synthesis of (-)-lasonolide A.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Marine Natural Products in Preclinical Cancer Studies: Ten Years of Advanced Total Synthesis.Marine drugs · 2025Review
- Catalytic Asymmetric Michael Reaction of Methyl Alkynyl Ketone Catalyzed by Diphenylprolinol Silyl Ether.ACS organic & inorganic Au · 2022Article
- Synthetic efforts on the road to marine natural products bearing 4-RSC advances · 2021Review
- The stereodivergent formation of 2,6-Chemical science · 2017Article
- Total Synthesis of (-)-Lasonolide A.Journal of the American Chemical Society · 2016Article
- Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the "Supply Problem".Marine drugs · 2016Review
- Broad Spectrum Enolate Equivalent for Catalytic Chemo-, Diastereo-, and Enantioselective Addition to N-Boc Imines.Journal of the American Chemical Society · 2015Article
- Activation of RAF1 (c-RAF) by the Marine Alkaloid Lasonolide A Induces Rapid Premature Chromosome Condensation.Marine drugs · 2015Article
- ProPhenol-catalyzed asymmetric additions by spontaneously assembled dinuclear main group metal complexes.Accounts of chemical research · 2015Article
- Regioselective allene hydroarylation via one-pot allene hydrosilylation/Pd-catalyzed cross-coupling.Organic letters · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Lasonolide A is a novel polyketide displaying potent anticancer activity across a broad range of cancer cell lines. Here, an enantioselective convergent total synthesis of the (-)-lasonolide A in 16 longest linear and 34 total steps is described. This approach significantly reduces the step count compared to other known syntheses. The synthetic strategy utilizes alkyne-bearing substrates as core building blocks and is highlighted by stitching together two similarly complex halves via a key Ru-catalyzed alkene-alkyne coupling and macrolactionization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.