ArticleBioMed research international2013
S100A12 and hBD2 correlate with the composition of the fecal microflora in ELBW infants and expansion of E. coli is associated with NEC.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The effect of antibiotics on the intestinal microbiota in children - a systematic review.Frontiers in allergy · 2024Pooled it
- Specific Signatures of the Gut Microbiota and Increased Levels of Butyrate in Children Treated with Fermented Cow's Milk Containing Heat-Killed Lactobacillus paracasei CBA L74.Applied and environmental microbiology · 2017Trial
- The role of fecal microbiota transplantation on the NLRP3-Caspase 1 pathway and anxiety like behavioral in the ulcerative colitis model in rats.Scientific reports · 2025Article
- Integrated analysis of serum metabolomics and fecal microbiome in infants with necrotizing enterocolitis.Frontiers in microbiology · 2025Article
- High hydrostatic pressure is similar to Holder pasteurization in preserving donor milk antimicrobial activity.Pediatric research · 2024Article
- Article
- S100A12 in Digestive Diseases and Health: A Scoping Review.Gastroenterology research and practice · 2020Article
- Using formalin fixed paraffin embedded tissue to characterize the preterm gut microbiota in necrotising enterocolitis and spontaneous isolated perforation using marginal and diseased tissue.BMC microbiology · 2019Article
- Recent Potential Noninvasive Biomarkers in Necrotizing Enterocolitis.Gastroenterology research and practice · 2019Review
- [Effect of Bifidobacterium on the expression of β-defensin-2 in intestinal tissue of neonatal rats with necrotizing enterocolitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018Article
- The Microbiota of the Extremely Preterm Infant.Clinics in perinatology · 2017Review
- Pathogenesis of NEC: Role of the innate and adaptive immune response.Seminars in perinatology · 2017Review
- Temporal bacterial and metabolic development of the preterm gut reveals specific signatures in health and disease.Microbiome · 2016Article
- Elevated fecal calprotectin levels during necrotizing enterocolitis are associated with activated neutrophils extruding neutrophil extracellular traps.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Gut Microbiome and Infant Health: Brain-Gut-Microbiota Axis and Host Genetic Factors.The Yale journal of biology and medicine · 2016Review
- Roles of nitric oxide and intestinal microbiota in the pathogenesis of necrotizing enterocolitis.Journal of pediatric surgery · 2016Review
- Fecal Human β-Defensin 2 in Children with Cystic Fibrosis: Is There a Diminished Intestinal Innate Immune Response?Digestive diseases and sciences · 2015Article
- The Human Antimicrobial Protein Calgranulin C Participates in Control of Helicobacter pylori Growth and Regulation of Virulence.Infection and immunity · 2015Article
- The impact of the milk glycobiome on the neonate gut microbiota.Annual review of animal biosciences · 2015Review
- Various forms of tissue damage and danger signals following hematopoietic stem-cell transplantation.Frontiers in immunology · 2015Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo describe the development of the gut microbiota in extremely low birth weight (ELBW) infants with and without necrotizing enterocolitis (NEC) between April 2008 and December 2009, fecal microflora was prospectively analyzed in fecal samples of all ELBW infants using real-time PCR assays. In addition, fecal inflammatory were measured.
resultsFecal microflora established early in ELBW infants and microbiota composition remained stable over the first 28 days of life except for the prevalence of C. difficile which decreased with decreasing antibiotic use. Infants who subsequently developed NEC had an increase of total bacterial count (9.8-fold) 24 h prior to clinical symptoms mainly due to the expansion of E. coli species (21.6-fold), whereas microbiota composition did not differ from healthy ELBW infants five days before onset of NEC. Importantly, S100A12 and hBD2 positively correlated with the total and E. coli bacterial CFU/g feces (r (2) 0.4 and 0.64, resp.).
conclusionsIn summary, we found evidence for a disturbed homeostasis between the intestinal microbiome and host immunity in ELBW infants with NEC. Moreover, S100A12 and hBD2 correlate with the fecal microbiota thus linking the intestinal innate immune response to the bacterial colonization thus possibly providing a diagnostic tool in the future.
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