ArticleThe Journal of clinical and aesthetic dermatology2013
Topical corticosteroid application and the structural and functional integrity of the epidermal barrier.
Article in The Journal of clinical and aesthetic dermatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Clinical, cytological, and microbiological evaluation of a topical boric acid-alcohol solution for the treatment of canine otitis externa: a randomized, open-label controlled clinical trial.Veterinary research communications · 2025Article
- Chronic Hand Eczema (CHE): A Narrative Review.Dermatology and therapy · 2025Review
- The Therapeutic Potential of Kiwi Extract as a Source of Cysteine Protease Inhibitors on DNCB-Induced Atopic Dermatitis in Mice and Human Keratinocyte HaCaT Cells.International journal of molecular sciences · 2025Article
- Chronic Hand Eczema.American journal of clinical dermatology · 2024Review
- Antidermatophyte activity and PK/PD of ME1111 in a guinea pig model of tinea corporis.The Journal of antibiotics · 2024Article
- Assessment of Cosmetic and Dermatological Properties and Safety of Use of Model Skin Tonics with Kombucha-Fermented Red Berry Extracts.International journal of molecular sciences · 2022Article
- A new avenue for treatment of chronic hand eczema.The British journal of dermatology · 2022Article
- Efinaconazole in Onychomycosis.American journal of clinical dermatology · 2022Review
- Seungmagalgeun-Tang, a Traditional Herbal Formula, Alleviates Skin Inflammation and Depression-Like Behavior in Atopic Dermatitis Mice under Sleep Deprivation Conditions.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Lycoperoside H, a Tomato Seed Saponin, Improves Epidermal Dehydration by Increasing Ceramide in the Stratum Corneum and Steroidal Anti-Inflammatory Effect.Molecules (Basel, Switzerland) · 2021Article
- Fixed-Combination Halobetasol Propionate and Tazarotene in the Treatment of Psoriasis: Narrative Review of Mechanisms of Action and Therapeutic Benefits.Dermatology and therapy · 2021Review
- Hand hygiene during COVID-19: Recommendations from the American Contact Dermatitis Society.Journal of the American Academy of Dermatology · 2020Review
- Topical Corticosteroid Therapy for Psoriasis-A Review of Clobetasol Propionate 0.025% Cream and the Clinical Relevance of Penetration Modification.The Journal of clinical and aesthetic dermatology · 2020Review
- Do We Utilize Our Knowledge of the Skin Protective Effects of Carotenoids Enough?Antioxidants (Basel, Switzerland) · 2019Review
- Impetiginized Dyshidrotic Eczema.Open access Macedonian journal of medical sciences · 2017Article
- Understanding the Epidermal Barrier in Healthy and Compromised Skin: Clinically Relevant Information for the Dermatology Practitioner: Proceedings of an Expert Panel Roundtable Meeting.The Journal of clinical and aesthetic dermatology · 2016Review
- Indian Association of Dermatologists, Venereologists and Leprologists (IADVL) Task Force against Recalcitrant Tinea (ITART) Consensus on the Management of Glabrous Tinea (INTACT).Indian dermatology online journalArticle
- Impetigo Incognito - A Case Series of Steroid Modified Impetigo.Indian dermatology online journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Topical corticosteroids are a very important part of the treatment of many skin disorders, especially eczematous dermatoses. When utilized properly and judiciously these agents often achieve excellent results in clearing or markedly improving many dermatological disorders. As some studies have shown, topical corticosteroids, despite their ability to decrease inflammation through several mechanisms, induce abnormalities in lipid synthesis and intercellular bilayer structure in the stratum corneum, which appear to prolong epidermal barrier recovery. These adverse effects may contribute to eariier eczematous flaring if measures to provide barrier repair are not undertaken. In addition, although topical corticosteroids are applied only to sites affected by the skin eruption, the incorporation of "barrier friendly" excipients into the vehicle that improve stratum corneum permeability barrier function and integrity is very rational.
Identifiers
24307921PMC3848648W2994313209What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.