ReviewInternational journal of endocrinology2013
Mechanisms of perivascular adipose tissue dysfunction in obesity.
Review in International journal of endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 102 citations in OpenAlex.
- Review
- The Gut-Adipose-Tumor Axis in Obesity-Related Cancer.Nutrients · 2026Review
- Non-Coding RNAs in Obesity-Driven Vascular Dysfunction: Mechanisms, EndMT, and Translational Opportunities.Chonnam medical journal · 2026Review
- TyG-ABSI as a novel metabolic obesity indicator for carotid plaque: an explainable machine learning study using SHAP in low-income population.BMC endocrine disorders · 2025Article
- Overweight-Related Hypertension in Middle-Aged Men Is Linked to Elevated Leptin, TNF-α, IL-6, Cholesterol, and Reduced Testosterone.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Article
- Predictive Value of CT Fractional Flow Reserve and Fat Attenuation Index Derived from Coronary CT Angiography for In-Stent Restenosis After Percutaneous Coronary Intervention.Therapeutics and clinical risk management · 2025Article
- Clinical correlates of perivascular adipose tissue in coronary artery disease and obesity.Frontiers in physiology · 2025Article
- Phenotypic and functional disparities in perivascular adipose tissue.Frontiers in physiology · 2024Review
- Perivascular Adipose Tissue Oxidative Stress in Obesity.Antioxidants (Basel, Switzerland) · 2023Review
- New Insights into Pathophysiology and New Risk Factors for ACS.Journal of clinical medicine · 2023Review
- Luseogliflozin and caloric intake restriction increase superoxide dismutase 2 expression, promote antioxidative effects, and attenuate aortic endothelial dysfunction in diet-induced obese mice.Journal of diabetes investigation · 2023Article
- Aortic stiffness is lower when PVAT is included: a novel ex vivo mechanics study.American journal of physiology. Heart and circulatory physiology · 2022Article
- Vasorelaxing properties of the perivascular tissue of the human radial artery.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2022Article
- Keeping It Local in Metabolic Disease: Adipose Tissue Paracrine Signaling and Insulin Resistance.Diabetes · 2022Review
- Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics.Clinical science (London, England : 1979) · 2022Review
- Identification of Piezo1 channels in perivascular adipose tissue (PVAT) and their potential role in vascular function.Pharmacological research · 2022Article
- The Role of Obesity-Induced Perivascular Adipose Tissue (PVAT) Dysfunction in Vascular Homeostasis.Nutrients · 2021Review
- PPARγ activation improves the microenvironment of perivascular adipose tissue and attenuates aortic stiffening in obesity.Journal of biomedical science · 2021Article
- The Interplay Between Adipose Tissue and Vasculature: Role of Oxidative Stress in Obesity.Frontiers in cardiovascular medicine · 2021Review
- Pathological Conversion of Mouse Perivascular Adipose Tissue by Notch Activation.Arteriosclerosis, thrombosis, and vascular biology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most blood vessels are surrounded by adipose tissue. Similarly to the adventitia, perivascular adipose tissue (PVAT) was considered only as a passive structural support for the vasculature, and it was routinely removed for isolated blood vessel studies. In 1991, Soltis and Cassis demonstrated for the first time that PVAT reduced contractions to noradrenaline in rat aorta. Since then, an important number of adipocyte-derived factors with physiological and pathophysiological paracrine vasoactive effects have been identified. PVAT undergoes structural and functional changes in obesity. During early diet-induced obesity, an adaptative overproduction of vasodilator factors occurs in PVAT, probably aimed at protecting vascular function. However, in established obesity, PVAT loses its anticontractile properties by an increase of contractile, oxidative, and inflammatory factors, leading to endothelial dysfunction and vascular disease. The aim of this review is to focus on PVAT dysfunction mechanisms in obesity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.