ArticleWorld journal of gastroenterology2013
Clinical characteristics and prognosis of young patients with colorectal cancer in Eastern China.
Article in World journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Survival rate of colorectal cancer in China: A systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Predictive power of circulating miRNAs in detecting colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Pooled it
- Trial
- Clinicopathological, prognostic, and molecular differences between microsatellite-stable colorectal cancer patients aged ≤ 30 years and > 30 years.BMC cancer · 2026Article
- The short-term and oncologic outcomes of younger VS older colorectal cancer patients undergoing primary surgery: a propensity score matching analysis.BMC cancer · 2022Article
- Development and Internal Validation of a Nomogram-Based Model to Predict Three-Year and Five-Year Overall Survival in Patients with Stage II/III Colon Cancer.Cancer management and research · 2022Article
- Article
- Long-Term Outcomes of Radical Surgery for Transverse Colon Cancer Staged from I to IIIC.Cancer management and research · 2020Article
- Determination of Cut Point in the Age of Colorectal Cancer Diagnosis Using a Survival Cure Model.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Early-onset colorectal cancer in young individuals.Molecular oncology · 2019Review
- Observational
- Poor prognosis of young patients with colorectal cancer: a retrospective study.International journal of colorectal disease · 2017Article
- Colorectal cancer in the young, many questions, few answers.World journal of gastrointestinal oncology · 2016Review
- Clinicopathological Characteristics and Prognosis of Colorectal Cancer in Chinese Adolescent Patients.Chinese medical journal · 2015Article
- Clinicopathological characteristics of colorectal cancer presenting under the age of 50.International journal of colorectal disease · 2015Observational
- Article
- Clinicogenomic Characteristics and Treatment of Young-Onset Colorectal Cancer Patients Treated With Palliative Therapy in Real-World Practice.Cancer control : journal of the Moffitt Cancer CenterArticle
- Biomarkers for Stratification in Colorectal Cancer: MicroRNAs.Cancer control : journal of the Moffitt Cancer CenterReview
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo explore the clinical characteristics and prognosis of young patients with colorectal cancer patients in Eastern China.
methodsA total of 1335 patients with colorectal cancer treated from December 1985 to December 2005 at the Second Affiliated Hospital of Zhejiang University School of Medicine were studied retrospectively. The patients were divided into two groups, a younger group (aged ≤ 30 years) and an older group (aged > 30 years), and comparison was made in the clinical characteristics and prognosis between the two groups. Chi-square test was used for data analysis of all categorical variables, and overall survival (OS) was calculated by the Kaplan-Meier method. A multivariate analysis was performed using the Cox model.
resultsThere were 42 (3.1%) and 1293 (96.9%) cases in the younger group and older group, respectively. Univariate analysis showed that the 5- and 10-year OS in the younger group were 33.9% and 26.1%, respectively, and those in the older group were 60.1% and 52.2%, respectively. Younger group had poor survival (χ(2) = 14.146, P = 0.000). Multivariate analysis revealed that age was not a dependent factor for prognosis (OR = 0.866, 95%CI: 0.592-1.269, P = 0.461). Stratified analysis indicated that in stage III and IV disease, the 5- and 10-year OS were 24.6% and 14.8% in the younger group, and 40.4% and 33.3% in the older group, respectively, with a significant difference between the two groups (χ(2) = 5.101, P = 0.024). In the subgroup of radical surgery, the 5- and 10-year OS were 44.3% and 34.2% in the younger group, and 69.6% and 60.5% in the older group, with a difference being significant between the two groups (χ(2) = 7.830, P = 0.005).
conclusionCompared with older patients, the younger patients have lower survival, especially in the subgroups of stage III and IV disease and radical surgery.
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