ArticleProceedings. Biological sciences2014
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
Article in Proceedings. Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed, 102 citations in OpenAlex.
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- Molecular evolution of aspartic protease gene family in vertebrates.Scientific reports · 2026Article
- Lack of gastric acidification reduces postprandial energy expenditure and protein digestion but not growth in Astyanax mexicanus.The Journal of experimental biology · 2026Article
- The molecular evolution of vertebrate organs.Nature ecology & evolution · 2026Review
- Aging Reduces Intestinal Stem Cell Activity in Killifish and Intermittent Fasting Reverses Intestinal Gene Expression Patterns.Aging cell · 2025Article
- Evolution of the Jawed Vertebrate (Gnathostomata) Stomach Through Gene Repertoire Loss: Findings from Agastric Species.Journal of developmental biology · 2025Article
- Co-option of immune and digestive cellular machinery to support photosymbiosis in amoebocytes of the upside-down jellyfish Cassiopea xamachana.The Journal of experimental biology · 2025Article
- Characterisation of intestinal amino acid and oleic acid absorption and their interaction in the Pacific spiny dogfish (Squalus suckleyi).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- Gene Loss DB: a curated database for gene loss in mammals-the cetacean collection.Database : the journal of biological databases and curation · 2025Article
- PseudoChecker2 and PseudoViz: automation and visualization of gene loss in the Genome Era.Bioinformatics advances · 2025Article
- Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates.Science advances · 2024Article
- Detecting adaptive changes in gene copy number distribution accompanying the human out-of-Africa expansion.Human genome variation · 2024Article
- Pseudogenization of NK3 homeobox 2 (Open biology · 2024Article
- slc26a12-A novel member of the slc26 family, is located in tandem with slc26a2 in coelacanths, amphibians, reptiles, and birds.Physiological reports · 2024Article
- Convergent gene losses and pseudogenizations in multiple lineages of stomachless fishes.Communications biology · 2024Article
- Immunohistochemical characterisation of the adult Nothobranchius furzeri intestine.Cell and tissue research · 2024Article
- Cross-species single-cell transcriptomic analysis of animal gastric antrum reveals intense porcine mucosal immunity.Cell regeneration (London, England) · 2023Article
- Decay of Skin-Specific Gene Modules in Pangolins.Journal of molecular evolution · 2023Article
- Differential roles of the fish chitinous membrane in gut barrier immunity and digestive compartments.EMBO reports · 2023Article
- Gain or Loss? Evidence for Legume Predisposition to Symbiotic Interactions with Rhizobia via Loss of Pathogen-Resistance-Related Gene Families.International journal of molecular sciences · 2022Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The stomach, a hallmark of gnathostome evolution, represents a unique anatomical innovation characterized by the presence of acid- and pepsin-secreting glands. However, the occurrence of these glands in gnathostome species is not universal; in the nineteenth century the French zoologist Cuvier first noted that some teleosts lacked a stomach. Strikingly, Holocephali (chimaeras), dipnoids (lungfish) and monotremes (egg-laying mammals) also lack acid secretion and a gastric cellular phenotype. Here, we test the hypothesis that loss of the gastric phenotype is correlated with the loss of key gastric genes. We investigated species from all the main gnathostome lineages and show the specific contribution of gene loss to the widespread distribution of the agastric condition. We establish that the stomach loss correlates with the persistent and complete absence of the gastric function gene kit--H(+)/K(+)-ATPase (Atp4A and Atp4B) and pepsinogens (Pga, Pgc, Cym)--in the analysed species. We also find that in gastric species the pepsinogen gene complement varies significantly (e.g. two to four in teleosts and tens in some mammals) with multiple events of pseudogenization identified in various lineages. We propose that relaxation of purifying selection in pepsinogen genes and possibly proton pump genes in response to dietary changes led to the numerous independent events of stomach loss in gnathostome history. Significantly, the absence of the gastric genes predicts that reinvention of the stomach in agastric lineages would be highly improbable, in line with Dollo's principle.
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