Trial reportTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Breast cancer sentinel lymph node mapping using near-infrared guided indocyanine green in comparison with blue dye.
Trial report in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Efficacy of indocyanine green fluorescence for the identification of non-palpable breast tumours: systematic review.BJS open · 2023Pooled it
- Indocyanine Green Fluorescence Versus Blue Dye or Radioisotope Regarding Detection Rate of Sentinel Lymph Node Biopsy and Nodes Removed in Breast Cancer: A Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2020Pooled it
- Diagnostic Performance of Indocyanine Green-Guided Sentinel Lymph Node Biopsy in Breast Cancer: A Meta-Analysis.PloS one · 2016Pooled it
- Perioperative diffuse optical imaging of blood flow distributions for porcine skin flap viability assessment.Journal of biomedical optics · 2026Article
- A Preclinical Study of a PSMA Ligand-Based Dual-Modality Probe for Radical Prostatectomy.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Perioperative diffuse optical imaging of blood flow distributions for porcine skin flap viability assessment.medRxiv : the preprint server for health sciences · 2026Article
- Adverse Effects of Intraparenchymal and Peritumoral Application of Isosulfan Blue Dye in Sentinel Lymph Node Mapping in Breast Cancer: A Systematic Review and Meta-Analysis.European journal of breast health · 2025Article
- Article
- Near-infrared laparoscopy with indocyanine green for axillary sentinel lymph node biopsy in early breast cancer: preliminary experience of a single unit.Gland surgery · 2021Article
- Awareness of Lymphatic Anatomy to Decrease False Negative Sentinel Lymph Node Rate in Breast Cancer.Indian journal of surgical oncology · 2019Article
- Murine Model Study of a New Receptor-Targeted Tracer for Sentinel Lymph Node in Breast Cancer.Journal of breast cancer · 2019Article
- Detection of Sentinel Lymph Nodes with Near-Infrared Imaging in Malignancies.Molecular imaging and biology · 2019Review
- A Novel Bimodal Imaging Agent Targeting HER2 Molecule of Breast Cancer.Journal of immunology research · 2018Article
- Fluorescence Imaging Topography Scanning System for intraoperative multimodal imaging.PloS one · 2017Article
- 10 % fluorescein sodium vs 1 % isosulfan blue in breast sentinel lymph node biopsy.World journal of surgical oncology · 2016Article
- Intraoperative indocyanine green fluorescence guidance for excision of nonpalpable breast cancer.World journal of surgical oncology · 2016Article
- Is blue dye still required during sentinel lymph node biopsy for breast cancer?Ecancermedicalscience · 2016Article
- A review of performance of near-infrared fluorescence imaging devices used in clinical studies.The British journal of radiology · 2015Review
- Evaluation of near infrared fluorescent labeling of monoclonal antibodies as a tool for tissue distribution.Drug metabolism and disposition: the biological fate of chemicals · 2014Article
- Imaging the lymphatic system.Microvascular research · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) was considered to have the potential to improve sentinel lymph node (SLN) mapping in breast cancer. Herein, we performed a randomized clinical trial to evaluate the effectiveness of ICG fluorescence imaging compared with blue dye imaging in SLN navigation surgery. We also analyzed lymph drainage pathways to identify targets for sentinel lymph node biopsy (SLNB). Finally, 68 consecutive patients diagnosed with breast cancer and who underwent SLNB between November 2010 and September 2012 were enrolled in the study. The cases were randomly grouped into either the ICG fluorescence or blue dye group, with 36 in the ICG fluorescence group and 32 in the blue dye group. Levels I and II axillary dissection was performed in all cases after SLNB. A single lymph drainage pathway was detected in 21 of 36 (58.3%) patients, and multiple lymph drainage pathways were detected in 15 of 36 (41.7%) cases. The detection rate of SLNB was higher by ICG fluorescence than by blue dye (97.2 vs. 81.3%, p < 0.05), as 3.6 SLNs were detected on average in the ICG fluorescence group compared to 2.1 in the blue dye group. However, the sensitivity and false-negative rate were similar in the two groups. In conclusion, ICG fluorescence was superior to blue dye for the identification of the SLN.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.