Evidence map›Paper›PMID 24307587›Full record

ArticleJournal of virology2014

Expression of herpes simplex virus 1 microRNAs in cell culture models of quiescent and latent infection.

Igor Jurak, Michael Hackenberg, Ju Youn Kim, Jean M Pesola, Roger D Everett, Chris M Preston, Angus C Wilson, Donald M Coen

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
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  3. Article
  4. Journal of virology · 2022
    Article
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  7. Article
  8. [Mechanisms of herpes simplex virus latency and reactivation].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Igor JurakDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
Michael Hackenberg
Ju Youn Kim
Jean M Pesola
Roger D Everett
Chris M Preston
Angus C Wilson
Donald M Coen
Harvard University · USNew York University · USMRC University of Glasgow Centre for Virus Research · GBUniversidad de Granada · ESUniversity of Glasgow · GB

Funding

VIral and host mechanisms that tilt the HSV lytic/latent balanceP01AI098681 · NIAID · HARVARD MEDICAL SCHOOL · PI PESOLA, JEAN M · 2013 to 2023
$19.2M
VIRAL AND CELLULAR GENES IN HSV LATENCY AND REACTIVATIONP01NS035138 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI COEN, DAVID · 1996 to 2010
$15.0M
INFECTIOUS DISEASES &BASIC MICROBIOLOGICAL MECHANISMST32AI007180 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WEISER, JEFFREY NEAL · 1985 to 2022
$8.9M
Virus Host Interactions that Regulate Translation in Cells Infected with HSV-1R01AI073898 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MOHR, IAN J · 2008 to 2020
$5.0M
MECHANISMS REGULATING HSV TK EXPRESSION DURING INFECTIONR01AI026126 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI COEN, DONALD M · 1988 to 2010
$3.2M
Antagonizing miRNAs in a strategy to cure HSV latencyR21AI105896 · NIAID · HARVARD MEDICAL SCHOOL · PI COEN, DONALD M · 2013 to 2014
$492k
Medical Research Council MC_U130169966NIAID NIH HHS P01 AI098681NIAID NIH HHS R01 AI026126NIAID NIH HHS R01 AI073898NIAID NIH HHS R21 AI105896NIAID NIH HHS T32 AI007180NIAID NIH HHS T32AI07180NINDS NIH HHS P01 NS035138NINDS NIH HHS P01 NS035138,
6 · The paper itself

Abstract

To facilitate studies of herpes simplex virus 1 latency, cell culture models of quiescent or latent infection have been developed. Using deep sequencing, we analyzed the expression of viral microRNAs (miRNAs) in two models employing human fibroblasts and one using rat neurons. In all cases, the expression patterns differed from that in productively infected cells, with the rat neuron pattern most closely resembling that found in latently infected human or mouse ganglia in vivo.

Indexed as

AnimalsCell Culture TechniquesFibroblastsHerpes SimplexHerpesvirus 1, HumanHigh-Throughput Nucleotide SequencingHumansMiceMicroRNAsNeuronsRatsVirus LatencyMicroRNAs

Identifiers

PMID24307587
PMCPMC3911564
OpenAlexW2030411301

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.