ArticleVeterinary research communications2014
Effect of carotenoid β-cryptoxanthin on cellular and humoral immune response in rabbit.
Article in Veterinary research communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Persimmon carotenoid extract rich in β-cryptoxanthin improves glucose homeostasis and reduces liver damage in high-fat-diet-induced type 2 diabetic and metabolic dysfunction-associated steatotic liver disease mice.Journal of the science of food and agriculture · 2026Article
- The Impact of Combined Vitamin D and A Supplementation on Clinical Outcomes in Patients with Pneumosepsis: A Randomized Double-Blind Clinical Trial.Advanced biomedical research · 2026Article
- Associations of multiple carotenoid co-exposure with all-cause and cause-specific mortality in US adults: a prospective cohort study.Frontiers in nutrition · 2024Article
- The evaluation of the supplementation of vitamin A, beta-carotene, and oxidized beta-carotene in prepubertal gilts.Journal of animal science · 2023Article
- Fat-soluble vitamins: updated review of their role and orchestration in human nutrition throughout life cycle with sex differences.Nutrition & metabolism · 2022Review
- Antioxidants and clinical outcomes of patients with coronavirus disease 2019: A systematic review of observational and interventional studies.Food science & nutrition · 2022Review
- Carotenoids from Persimmon (Pharmaceutics · 2021Article
- Carotenoids: Therapeutic Strategy in the Battle against Viral Emerging Diseases, COVID-19: An Overview.Preventive nutrition and food science · 2021Review
- The Influence of Nutritional Factors on Immunological Outcomes.Frontiers in immunology · 2021Review
- Chili Pepper Carotenoids: Nutraceutical Properties and Mechanisms of Action.Molecules (Basel, Switzerland) · 2020Review
- Marine Bacteria versus Microalgae: Who Is the Best for Biotechnological Production of Bioactive Compounds with Antioxidant Properties and Other Biological Applications?Marine drugs · 2019Review
- Role of Vitamin A in the Immune System.Journal of clinical medicine · 2018Review
- Exploring the Valuable Carotenoids for the Large-Scale Production by Marine Microorganisms.Marine drugs · 2018Review
- Prospects on the Use ofFrontiers in microbiology · 2018Review
- Non-Provitamin A and Provitamin A Carotenoids as Immunomodulators: Recommended Dietary Allowance, Therapeutic Index, or Personalized Nutrition?Oxidative medicine and cellular longevity · 2018Review
- Carotenoids: biochemistry, pharmacology and treatment.British journal of pharmacology · 2017Review
- Absorption, metabolism, and functions of β-cryptoxanthin.Nutrition reviews · 2016Review
- Extract from a mutant Rhodobacter sphaeroides as an enriched carotenoid source.Food & nutrition research · 2016Article
- Carotenoids from Haloarchaea and Their Potential in Biotechnology.Marine drugs · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beta-cryptoxanthin (b-Cr) is a pro-vitamin A and one of the major carotenoids that can be commonly found in mammalian serum and tissues. Foods rich in certain fatty acids are known to be effective to gain a healthy immune system. In the present study, we evaluated the effect of b-Cr on rabbit humoral and cellular immune responses to have a better vision about the mechanism of effect of carotenoids on immune system. Twenty rabbits were randomly divided into five groups (4 per group): Groups consisted of: 1) control group (normal saline; 2) b-Cr (control); 3) vaccine control; 4) 5 mg/kg b-Cr o.p. + vaccine; 5) 10 mg/kg b-Cr o.p. + vaccine. Blood samples were obtained from the marginal ear artery at three time points: days 0, 14 and 21 of the study. Blood CD4+ and CD8+ lymphocytes and Serum Immunoglobulin and Cytokines content were evaluated. Results show that b-Cr administration increased the blood CD4+ lymphocytes count (P > 0.01). Serum IgG, IgM and IgA levels increased (P > 0.05) following b-Cr administration. b-Cr treatment increased serum IL-4 levels (P > 0.05). According to presented results, b-Cr may increase the humoral immunity in mammals. So, it would possible has a potentially beneficial effect on health and on prevention of the immunity related diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.