Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2014
Delayed sodium 18F-fluoride PET/CT imaging does not improve quantification of vascular calcification metabolism: results from the CAMONA study.
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- Trial
- Thoracic aorta calcification but not inflammation is associated with increased cardiovascular disease risk: results of the CAMONA study.European journal of nuclear medicine and molecular imaging · 2017Trial
- Automated joint segmentation enables quantitative molecular imaging of degeneration with [¹⁸F]FDG and [¹⁸F]NaF PET/CT.European journal of nuclear medicine and molecular imaging · 2026Article
- The emerging role of ¹⁸F-NaF PET/CT in osteoporosis: an emphasis on its application for the evaluation and management of lumbar spine osteoporosis.EJNMMI research · 2026Review
- Article
- NaF-PET/CT imaging of atherosclerosis in type 2 diabetes: Associations with sex and history of cardiovascular events in a 2-year follow-up study.European journal of nuclear medicine and molecular imaging · 2025Article
- Associations of subclinical microcalcification and inflammation with carotid atheroma development: a dual-tracer PET/CT study.European journal of nuclear medicine and molecular imaging · 2025Observational
- Advances in positron emission tomography tracers related to vascular calcification.Annals of nuclear medicine · 2022Review
- PET/CT imaging of spinal inflammation and microcalcification in patients with low back pain: A pilot study on the quantification by artificial intelligence-based segmentation.Clinical physiology and functional imaging · 2022Article
- Application ofQuantitative imaging in medicine and surgery · 2022Article
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Determinants ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Assessment of atherosclerosis in multiple myeloma and smoldering myeloma patients usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- (18)F-sodium fluoride PET in multiple myeloma: Linking cancer to atherosclerosis?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Two-year change in 18F-sodium fluoride uptake in major arteries of healthy subjects and angina pectoris patients.The international journal of cardiovascular imaging · 2021Article
- Alavi-Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden.Diagnostics (Basel, Switzerland) · 2021Article
- Review
- Quantitative thoracic aorta calcification assessment byEuropean radiology · 2021Article
- Critical review of PET imaging for detection and characterization of the atherosclerotic plaques with emphasis on limitations of FDG-PET compared to NaF-PET in this setting.American journal of nuclear medicine and molecular imaging · 2021Review
- Reinventing Molecular Imaging with Total-Body PET, Part II: Clinical Applications.PET clinics · 2020Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to determine if delayed sodium (18)F-fluoride (Na(18)F) PET/CT imaging improves quantification of vascular calcification metabolism. Blood-pool activity can disturb the arterial Na(18)F signal. With time, blood-pool activity declines. Therefore, delayed imaging can potentially improve quantification of vascular calcification metabolism. METHODS AND
resultsTwenty healthy volunteers and 18 patients with chest pain were prospectively assessed by triple time-point PET/CT imaging at approximately 45, 90, and 180 minutes after Na(18)F administration. For each time point, global uptake of Na(18)F was determined in the coronary arteries and thoracic aorta by calculating the blood-pool-corrected maximum standardized uptake value (cSUV(MAX)). A target-to-background ratio (TBR) was calculated to determine the contrast resolution at 45, 90, and 180 minutes. Furthermore, we assessed whether the acquisition time-point affected the relation between cSUV(MAX) and the estimated 10-year risk for fatal cardiovascular disease (SCORE %). Coronary cSUV(MAX) (P = .533) and aortic cSUV(MAX) (P = .654) remained similar with time, whereas the coronary TBR (P < .0001) and aortic TBR (P < .0001) significantly increased with time. Even though the contrast resolution improved with time, positive correlations between SCORE % and coronary cSUV(MAX) (P < .020) and aortic cSUV(MAX) (P < .005) were observed at all investigated time points.
conclusionsDelayed Na(18)F PET/CT imaging does not improve quantification of vascular calcification metabolism. Although contrast resolution improves with time, arterial Na(18)F avidity is invariant to the time between Na(18)F administration and PET/CT acquisition. Therefore, the optimal PET/CT acquisition time-point to quantify vascular calcification metabolism is achieved as early as 45 minutes after Na(18)F administration.
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