ArticleMolecular and cellular biochemistry2014
MicroRNA-128 regulates the differentiation of rat bone mesenchymal stem cells into neuron-like cells by Wnt signaling.
Article in Molecular and cellular biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- MSC based gene delivery methods and strategies improve the therapeutic efficacy of neurological diseases.Bioactive materials · 2023Review
- An Overview of Mesenchymal Stem Cell-based Therapy Mediated by Noncoding RNAs in the Treatment of Neurodegenerative Diseases.Stem cell reviews and reports · 2022Review
- [Activation of mir-30a-wnt/β-catenin signaling pathway upregulates cathepsin K expression to promote cementogenic differentiation of periodontal ligament stem cells].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- miR-762 regulates the proliferation and differentiation of retinal progenitor cells by targeting NPDC1.Cell cycle (Georgetown, Tex.) · 2020Article
- Polydatin promotes the neuronal differentiation of bone marrow mesenchymal stem cells in vitro and in vivo: Involvement of Nrf2 signalling pathway.Journal of cellular and molecular medicine · 2020Article
- MiR-128 promotes osteogenic differentiation of bone marrow mesenchymal stem cells in rat by targeting DKK2.Bioscience reports · 2020Article
- miR-128a Acts as a Regulator in Cardiac Development by Modulating Differentiation of Cardiac Progenitor Cell Populations.International journal of molecular sciences · 2020Article
- Role of microRNA in inner ear stem cells and related research progress.American journal of stem cells · 2020Review
- Fasudil may induce the differentiation of bone marrow mesenchymal stem cells into neuron‑like cells via the Wnt/β‑catenin pathway.Molecular medicine reports · 2019Article
- MicroRNA-mediated regulation of BM-MSCs differentiation into sweat gland-like cells: targeting NF-κB.Journal of molecular histology · 2019Article
- Hypoxia inducible factor 1α promotes survival of mesenchymal stem cells under hypoxia.American journal of translational research · 2017Article
- AurkA controls self-renewal of breast cancer-initiating cells promoting wnt3a stabilization through suppression of miR-128.Scientific reports · 2016Article
- TET2 Negatively Regulates Nestin Expression in Human Melanoma.The American journal of pathology · 2016Article
- The role of stem cell therapy in multiple sclerosis: An overview of the current status of the clinical studies.Advanced biomedical research · 2016Review
- Understanding the Pathogenesis of Slow-Transit Constipation: One Step Forward.Digestive diseases and sciences · 2015Article
- Immunomodulation in stem cell differentiation into neurons and brain repair.Stem cell reviews and reports · 2015Review
- A Perspective on the Role of microRNA-128 Regulation in Mental and Behavioral Disorders.Frontiers in cellular neuroscience · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone marrow mesenchymal stem cells (BMSCs) are a source of multipotent stem cells ideally suited for various cell-based therapies. BMSCs can differentiate into neuron-like cells under the appropriate conditions. MicroRNAs are members of a family of noncoding small RNAs that regulate gene expression at the posttranscriptional level, either by inhibiting mRNA translation or by promoting mRNA degradation. MicroRNAs play an important role in the differentiation of BMSCs into neurons. MicroRNA-128, a brain-enriched microRNA, was recently found to be necessary in the neural differentiation of BMSCs. Studies have shown that Wnt signaling pathway is involved in regulating MSC differentiation. Our goal here was to investigate whether microRNA-128 can regulate the differentiation of BMSCs through modulation of Wnt3a, a key component of the Wnt signaling pathway. By means of dual-luciferase reporter assay, we describe for the first time that by binding to a specific site in the 3'-UTR of Wnt3a in BMSCs, downregulated microRNA-128 may lead to the neural differentiation of mesenchymal stem cells. Transfection of microRNA-128 mimic decreased the nerve cell markers and Wnt3a expression levels. On the other hand, the inhibition of microRNA-128 significantly elevated the nerve cell markers as well as the Wnt3a expression levels. This suggests that microRNA-128 acts as an endogenous attenuator of BMSCs differentiation into neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.