ArticleInternational journal of colorectal disease2014
Nerve supply to the internal anal sphincter differs from that to the distal rectum: an immunohistochemical study of cadavers.
Article in International journal of colorectal disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Surgeons' assessment of internal anal sphincter nerve supply during TaTME - inbetween expectations and reality.Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy · 2016Trial
- Historical aspects of anatomic landmarks during pull-through for hirschsprung disease: focusing on resection levels of the aganglionic rectum and rectal cuff issues.Pediatric surgery international · 2025Review
- [Surgical anatomy of the anorectum].Chirurgie (Heidelberg, Germany) · 2025Review
- Diagnosis and Treatment of Low Anterior Resection Syndrome.Journal of the anus, rectum and colon · 2025Review
- Anal carcinoma - exploring the epidemiology, risk factors, pathophysiology, diagnosis, and treatment.World journal of experimental medicine · 2024Review
- Anatomical Location of the Vesical Branches of the Inferior Hypogastric Plexus in Human Cadavers.Diagnostics (Basel, Switzerland) · 2024Article
- Faecal incontinence in adults.Nature reviews. Disease primers · 2022Review
- Diagnosis of colonic dysmotility associated with autonomic dysfunction in patients with chronic refractory constipation.Scientific reports · 2022Article
- Observational
- [Low anterior resection syndrome-Causes and treatment approaches].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021Review
- Management guidelines for low anterior resection syndrome - the MANUEL project.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2021Article
- Quality of Life in Patients With Rectal Resections and End-to-End Primary Anastomosis Using a Standardized Perioperative Pathway.Frontiers in surgery · 2021Article
- Control of Motility in the Internal Anal Sphincter.Journal of neurogastroenterology and motility · 2019Article
- Innervation of the entire internal anal sphincter in a mouse model of Hirschsprung's disease: a first report.Pediatric surgery international · 2019Article
- Outcome of bowel function following anterior resection for rectal cancer-an analysis using the low anterior resection syndrome (LARS) score.International journal of colorectal disease · 2018Article
- Characterization of Simultaneous Pressure Waves as Biomarkers for Colonic Motility Assessed by High-Resolution Colonic Manometry.Frontiers in physiology · 2018Article
- Neuroanatomical autonomic substrates of brainstem-gut circuitry identified using transsynaptic tract-tracing with pseudorabies virus recombinants.American journal of clinical and experimental immunology · 2018Article
- Human nasociliary nerve with special reference to its unique parasympathetic cutaneous innervation.Anatomy & cell biology · 2016Article
- Three Gaseous Neurotransmitters, Nitric oxide, Carbon Monoxide, and Hydrogen Sulfide, Are Involved in the Neurogenic Relaxation Responses of the Porcine Internal Anal Sphincter.Journal of neurogastroenterology and motility · 2016Article
- Topography of the extrinsic internal anal sphincter nerve supply during laparoscopic-assisted TAMIS TME: five key zones of risk from the surgeons' view.International journal of colorectal disease · 2015Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeFecal incontinence is a common problem after anal sphincter-preserving operations. The intersphincteric autonomic nerves supplying the internal anal sphincter (IAS) are formed by the union of: (1) nerve fibers from Auerbach's nerve plexus of the most distal part of the rectum and (2) the inferior rectal branches of the pelvic plexus (IRB-PX) running along the conjoint longitudinal muscle coat. The aim of the present study is to identify the detailed morphology of nerves to the IAS.
methodsThe study comprised histological and immunohistochemical evaluations of paraffin-embedded sections from a large block of anal canal from the preserved 10 cadavers.
resultsThe IRB-PX came from the superior aspect of the levator ani and ran into the anal canal on the anterolateral side. These nerves contained both sympathetic and parasympathetic fibers, but the sympathetic content was much higher than in nerves from the distal rectum. All intramural ganglion cells in the distal rectum were neuronal nitric oxide synthase-positive and tyrosine hydroxylase-negative and were restricted to above the squamous-columnar epithelial junction. Parasympathetic nerves formed a lattice-like plexus in the circular smooth muscles of the distal rectum, whereas the IAS contained short, longitudinally running sympathetic and parasympathetic nerves, although sympathetic nerves were dominant.
conclusionsThe major autonomic nerve input to the IAS seemed not to originate from the distal rectum but from the IRB-PX. Injury to the IRB-PX during surgery seemed to result in loss of innervation to the major part of the IAS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.