ReviewNeurosurgical review2014
Factors affecting formation and rupture of intracranial saccular aneurysms.
Review in Neurosurgical review, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 56 citations in OpenAlex.
- Obstructive Sleep Apnea and Its Influence on Intracranial Aneurysm.Journal of clinical medicine · 2023Article
- A PDE-regularized smoothing method for space-time data over manifolds with application to medical data.International journal for numerical methods in biomedical engineering · 2022Article
- Disturbed flow's impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review.Journal of cellular physiology · 2022Review
- A scoring system to discriminate blood blister-like aneurysms: a multidimensional study using patient-specific model.Neurosurgical review · 2021Article
- Anterior Communicating Artery Aneurysms: Anatomical Considerations and Microsurgical Strategies.Frontiers in neurology · 2020Review
- A Simple Scoring Model for Prediction of Rupture Risk of Anterior Communicating Artery Aneurysms.Frontiers in neurology · 2019Article
- A Median Artery of the Corpus Callosum.Cureus · 2018Article
- Hemodynamic impingement and the initiation of intracranial side-wall aneurysms.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2018Article
- Rare Coding Variants in ANGPTL6 Are Associated with Familial Forms of Intracranial Aneurysm.American journal of human genetics · 2018Article
- A Review of the Genetics of Intracranial Berry Aneurysms and Implications for Genetic Counseling.Journal of genetic counseling · 2017Review
- Prevalence and Characteristics of Unruptured Cerebral Aneurysms in Ischemic Stroke Patients.Journal of stroke · 2016Article
- Risk Factors for the Rupture of Bifurcation Intracranial Aneurysms Using CT Angiography.Yonsei medical journal · 2016Article
- Risk Factors for the Rupture of Middle Cerebral Artery Bifurcation Aneurysms Using CT Angiography.PloS one · 2016Article
- Diabetes may affect intracranial aneurysm stabilization in older patients: Analysis based on intraoperative findings.Surgical neurology international · 2016Article
- Genetic associations of intracranial aneurysm formation and sub-arachnoid hemorrhage.Asian journal of neurosurgeryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 9 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unruptured intracranial aneurysms represent a decisional challenge. Treatment risks have to be balanced against an unknown probability of rupture. A better understanding of the physiopathology is the basis for a better prediction of the natural history of an individual patient. Knowledge about the possible determining factors arises from a careful comparison between ruptured versus unruptured aneurysms and from the prospective observation and analysis of unbiased series with untreated, unruptured aneurysms. The key point is the correct identification of the determining variables for the fate of a specific aneurysm in a given individual. Thus, the increased knowledge of mechanisms of formation and eventual rupture of aneurysms should provide significant clues to the identification of rupture-prone aneurysms. Factors like structural vessel wall defects, local hemodynamic stress determined also by peculiar geometric configurations, and inflammation as trigger of a wall remodeling are crucial. In this sense the study of genetic modifiers of inflammatory responses together with the computational study of the vessel tree might contribute to identify aneurysms prone to rupture. The aim of this article is to underline the value of a unifying hypothesis that merges the role of geometry, with that of hemodynamics and of genetics as concerns vessel wall structure and inflammatory pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.