Evidence map›Paper›PMID 24306080›Full record

ArticleIntensive care medicine2014

Patients with faecal peritonitis admitted to European intensive care units: an epidemiological survey of the GenOSept cohort.

Ascanio Tridente, Geraldine M Clarke, A Walden, S McKechnie, P Hutton, G H Mills, A C Gordon, P A H Holloway, J-D Chiche, J Bion and 4 more

Open access · bronzeAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Intensive care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Pooled it
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  15. Netrin-1: A Modulator of Macrophage Driven Acute and Chronic Inflammation.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 3 countries.

Ascanio TridenteWhiston Hospital, Prescot, Merseyside and Academic Unit of Medical Education, The Medical School, University of Sheffield, Sheffield, UK.
Geraldine M ClarkeThe Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
A WaldenIntensive Care Unit, Royal Berkshire Hospital, Reading, UK.
S McKechnieIntensive Care Unit, John Radcliffe Hospital, Oxford, UK.
P HuttonIntensive Care Unit, John Radcliffe Hospital, Oxford, UK.
G H MillsIntensive Care Unit, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
A C GordonImperial College, London, UK.
P A H HollowayImperial College, London, UK.
J-D ChicheHospital Cochin, Paris, France.
J BionSchool of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK.
F StuberDepartment of Anaesthesiology and Pain Medicine, Bern University Hospital and University of Bern, Bern, Switzerland.
C GarrardIntensive Care Unit, John Radcliffe Hospital, Oxford, UK.
C J HindsBarts and the London Queen Mary School of Medicine, London, UK. c.j.hinds@qmul.ac.uk.
GenOSept Investigators
Centre for Human Genetics · GBHôpital Cochin · FRNorthern General Hospital · GBQueen Mary University of London · GBUniversity of Bern · CHImperial College London · GBJohn Radcliffe Hospital · GBRoyal Berkshire Hospital · GBWhiston Hospital · GB

Funding

Department of Health NIHR/CS/009/007
6 · The paper itself

Abstract

introductionFaecal peritonitis (FP) is a common cause of sepsis and admission to the intensive care unit (ICU). The Genetics of Sepsis and Septic Shock in Europe (GenOSept) project is investigating the influence of genetic variation on the host response and outcomes in a large cohort of patients with sepsis admitted to ICUs across Europe. Here we report an epidemiological survey of the subset of patients with FP.

objectivesTo define the clinical characteristics, outcomes and risk factors for mortality in patients with FP admitted to ICUs across Europe.

methodsData was extracted from electronic case report forms. Phenotypic data was recorded using a detailed, quality-assured clinical database. The primary outcome measure was 6-month mortality. Patients were followed for 6 months. Kaplan-Meier analysis was used to determine mortality rates. Cox proportional hazards regression analysis was employed to identify independent risk factors for mortality.

resultsData for 977 FP patients admitted to 102 centres across 16 countries between 29 September 2005 and 5 January 2011 was extracted. The median age was 69.2 years (IQR 58.3-77.1), with a male preponderance (54.3%). The most common causes of FP were perforated diverticular disease (32.1%) and surgical anastomotic breakdown (31.1%). The ICU mortality rate at 28 days was 19.1%, increasing to 31.6% at 6 months. The cause of FP, pre-existing co-morbidities and time from estimated onset of symptoms to surgery did not impact on survival. The strongest independent risk factors associated with an increased rate of death at 6 months included age, higher APACHE II score, acute renal and cardiovascular dysfunction within 1 week of admission to ICU, hypothermia, lower haematocrit and bradycardia on day 1 of ICU stay.

conclusionsIn this large cohort of patients admitted to European ICUs with FP the 6 month mortality was 31.6%. The most consistent predictors of mortality across all time points were increased age, development of acute renal dysfunction during the first week of admission, lower haematocrit and hypothermia on day 1 of ICU admission.

Indexed as

FecesAgedEuropeFemaleHealth SurveysHospitalizationHumansIntensive Care UnitsMaleMiddle AgedMultivariate AnalysisPeritonitisPrognosisProspective StudiesRisk Factors

Identifiers

PMID24306080
OpenAlexW2154000867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.