ArticleBreast cancer research and treatment2014
Does shear wave ultrasound independently predict axillary lymph node metastasis in women with invasive breast cancer?
Article in Breast cancer research and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Prediction of sentinel lymph node status in patients with early breast cancer using breast imaging as an alternative to surgical staging-a systematic review and meta-analysis.Systematic reviews · 2025Pooled it
- Hierarchical Collagen Nanofiber Gels Recapitulate a Physiologically Relevant Tumor Stromal Microenvironment.Advanced healthcare materials · 2026Article
- Predicting axillary lymph node metastasis in breast cancer via quantitative analysis of VueBox ultrasound contrast-enhanced imaging combined with multimodal feature fusion.Quantitative imaging in medicine and surgery · 2026Article
- Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2025Review
- An Intraoperative Ultrasound Evaluation of Axillary Lymph Nodes: Cassandra Predictive Models in Patients with Breast Cancer-A Multicentric Study.Medicina (Kaunas, Lithuania) · 2024Article
- Predictive nomogram using multimodal ultrasonographic features for axillary lymph node metastasis in early‑stage invasive breast cancer.Oncology letters · 2024Article
- Ultrasound-based radiomics nomogram for predicting axillary lymph node metastasis in early-stage breast cancer.La Radiologia medica · 2024Article
- Elasticity Values as a Predictive Modality for Response to Neoadjuvant Chemotherapy in Breast Cancer.Cancers · 2024Article
- The value of microvascular Doppler ultrasound technique, qualitative or quantitative shear-wave elastography of breast lesions for predicting axillary nodal burden in patients with breast cancer.Quantitative imaging in medicine and surgery · 2024Article
- The correlation between multi-mode ultrasonographic features of breast cancer and axillary lymph node metastasis.Frontiers in oncology · 2024Article
- Strain ultrasonic elastography imaging features of locally advanced breast cancer: association with response to neoadjuvant chemotherapy and recurrence-free survival.BMC medical imaging · 2023Article
- Usefulness of machine learning and deep learning approaches in screening and early detection of breast cancer.Heliyon · 2023Review
- Ultra-Rapid and Specific Gelation of Collagen Molecules for Transparent and Tough Gels by Transition Metal Complexation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Progress in research on ultrasound radiomics for predicting the prognosis of breast cancer.Cancer innovation · 2023Review
- An improved nomogram including elastography for the prediction of non-sentinel lymph node metastasis in breast cancer patients with 1 or 2 sentinel lymph node metastases.Frontiers in oncology · 2023Article
- In Search of an Imaging Classification of Adenomyosis: A Role for Elastography?Journal of clinical medicine · 2022Review
- Collagen fiber features and COL1A1: are they associated with elastic parameters in breast lesions, and can COL1A1 predict axillary lymph node metastasis?BMC cancer · 2022Article
- Radiomics model based on shear-wave elastography in the assessment of axillary lymph node status in early-stage breast cancer.European radiology · 2022Article
- Effectiveness of Quantitative Shear Wave Elastography for the Prediction of Axillary Lymph Node Metastasis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Comprehensive Risk System Based on Shear Wave Elastography and BI-RADS Categories in Assessing Axillary Lymph Node Metastasis of Invasive Breast Cancer-A Multicenter Study.Frontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shear wave elastography (SWE) shows promise as an adjunct to greyscale ultrasound examination in assessing breast masses. In breast cancer, higher lesion stiffness on SWE has been shown to be associated with features of poor prognosis. The purpose of this study was to assess whether lesion stiffness at SWE is an independent predictor of lymph node involvement. Patients with invasive breast cancer treated by primary surgery, who had undergone SWE examination were eligible. Data were retrospectively analysed from 396 consecutive patients. The mean stiffness values were obtained using the Aixplorer® ultrasound machine from SuperSonic Imagine Ltd. Measurements were taken from a region of interest positioned over the stiffest part of the abnormality. The average of the mean stiffness value obtained from each of two orthogonal image planes was used for analysis. Associations between lymph node involvement and mean lesion stiffness, invasive cancer size, histologic grade, tumour type, ER expression, HER-2 status and vascular invasion were assessed using univariate and multivariate logistic regression. At univariate analysis, invasive size, histologic grade, HER-2 status, vascular invasion, tumour type and mean stiffness were significantly associated with nodal involvement. Nodal involvement rates ranged from 7 % for tumours with mean stiffness <50 kPa to 41 % for tumours with a mean stiffness of >150 kPa. At multivariate analysis, invasive size, tumour type, vascular invasion, and mean stiffness maintained independent significance. Mean stiffness at SWE is an independent predictor of lymph node metastasis and thus can confer prognostic information additional to that provided by conventional preoperative tumour assessment and staging.
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