ArticlePediatric nephrology (Berlin, Germany)2014
Near-infrared spectroscopy as continuous real-time monitoring for kidney graft perfusion.
Article in Pediatric nephrology (Berlin, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 30 citations in OpenAlex.
- Real-time organ perfusion monitoring of human kidney transplants usingRoyal Society open science · 2025Article
- Near-Infrared Spectroscopic Mapping of the Human Epicardium.Journal of biophotonics · 2025Article
- The relationship between trajectories of renal oxygen saturation and acute kidney injury: a prospective cohort study with a secondary analysis.Aging clinical and experimental research · 2024Article
- Changes in regional oxygen saturation of the kidney and brain of infants during hospitalization.Journal of clinical monitoring and computing · 2022Observational
- Intraoperative Near-Infrared Spectroscopy Monitoring of Renal Allograft Reperfusion in Kidney Transplant Recipients: A Feasibility and Proof-of-Concept Study.Journal of clinical medicine · 2021Article
- End-organ saturations correlate with aortic blood flow estimates by echocardiography in the extremely premature newborn - an observational cohort study.BMC pediatrics · 2021Observational
- Acute Kidney Injury and Renal Regional Oxygen Saturation During Pediatric Liver Transplantation.Annals of transplantation · 2020Article
- NIRS-based monitoring of kidney graft perfusion.PloS one · 2020Article
- Monitoring kidney optical properties during cold storage preservation with spatial frequency domain imaging.Journal of biomedical optics · 2019Article
- Near-infrared spectroscopy for monitoring renal transplant perfusion.Pediatric nephrology (Berlin, Germany) · 2014Article
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10 authors at 1 institution in 1 country.
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Abstract
backgroundNear-infrared spectroscopy (NIRS) is a non-invasive technique designed to study regional oxygenation (rSO(2)) by measuring the absorption of chromophores. This study investigated the role of NIRS in the real-time monitoring of kidney graft perfusion for 72 h post-transplantation.
methodsConsecutive children undergoing living related donor (LRD) or deceased donor (DD) kidney transplantation (KTP) were prospectively enrolled between April 2010 and August 2011. Renal rSO(2) values were registered continuously for 3 days and correlated with hourly urine output, serum creatinine, and urinary neutrophil gelatinase-associated lipocalin (u-NGAL).
resultsTwenty-four children were included, 6 underwent LRD and 18 DD KTP. Median age was 12.5 years (interquartile range [IQR] 3.5-16.6) and median body weight was 37 kg (IQR 13-49.7). Four patients experienced delayed graft function (DGF). Renal Doppler ultrasound showed normal vascularization patterns in all children. Median basal renal rSO(2) value was 68.8 % (IQR 59.3-76.2), significantly lower than the end-of-period result (83.6 %; IQR 79.2-90.4; p < 0.0001). Renal rSO(2) values showed significant correlation with serum creatinine (rs = -0.62; p < 0.05) and estimated glomerular filtration rate (eGFR) (rs = 0.64; p < 0.05). No correlation was shown between rSO(2) and diuresis. Increased rSO(2) was also found in patients who experienced DGF. u-NGAL exhibited a trend toward a decrease from baseline in both DD and LRD KTPs, with a strong negative correlation with rSO(2).
conclusionsrSO(2) assessed by NIRS strongly correlates with common markers of kidney graft function and perfusion, allowing continuous real-time monitoring of blood flow in renal grafts.
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