ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Memory consolidation by replay of stimulus-specific neural activity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 2 of them syntheses that pooled it.
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Who cites it
129 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Promoting memory consolidation during sleep: A meta-analysis of targeted memory reactivation.Psychological bulletin · 2020Pooled it
- Melatonin for sleep disorders and cognition in dementia: a meta-analysis of randomized controlled trials.American journal of Alzheimer's disease and other dementias · 2015Pooled it
- Reinstatement of distributed cortical oscillations occurs with precise spatiotemporal dynamics during successful memory retrieval.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Memory reactivation during rest supports upcoming learning of related content.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Reinstatement of associative memories in early visual cortex is signaled by the hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Boosting long-term memory via wakeful rest: intentional rehearsal is not necessary, consolidation is sufficient.PloS one · 2014Trial
- Context-Aware Evidence-Gated Plasticity for Multi-Goal Learning in Spiking Neural Networks.Research square · 2026Article
- Two-factor synaptic plasticity enables memory consolidation during neuronal burst firing.PNAS nexus · 2026Article
- Context-Aware Evidence-Gated Plasticity for Multi-Goal Learning in Spiking Neural Networks.bioRxiv : the preprint server for biology · 2026Article
- Reactivation during sleep segregates the neural representations of episodic memories.bioRxiv : the preprint server for biology · 2026Article
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- Online supervised learning of temporal patterns in biological neural networks under feedback control.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The default mode network: where spontaneous thought meets memory consolidation.Current opinion in behavioral sciences · 2026Article
- Two-factor synaptic consolidation reconciles robustness with pruning and homeostatic scaling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Spontaneous reinstatement of episodic memories in the developing human brain.bioRxiv : the preprint server for biology · 2025Article
- Prediction Error-Related Memory Enhancement Depends on the Neural State Surrounding the Prediction Error Event.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Task-relevant representational spaces in human memory traces.PLoS computational biology · 2025Article
- Local inhibitory circuits mediate cortical reactivations and memory consolidation.Science advances · 2025Article
- Study-phase reinstatement predicts subsequent recall.Nature neuroscience · 2025Article
69 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memory consolidation transforms initially labile memory traces into more stable representations. One putative mechanism for consolidation is the reactivation of memory traces after their initial encoding during subsequent sleep or waking state. However, it is still unknown whether consolidation of individual memory contents relies on reactivation of stimulus-specific neural representations in humans. Investigating stimulus-specific representations in humans is particularly difficult, but potentially feasible using multivariate pattern classification analysis (MVPA). Here, we show in healthy human participants that stimulus-specific activation patterns can indeed be identified with MVPA, that these patterns reoccur spontaneously during postlearning resting periods and sleep, and that the frequency of reactivation predicts subsequent memory for individual items. We conducted a paired-associate learning task with items and spatial positions and extracted stimulus-specific activity patterns by MVPA in a simultaneous electroencephalography and functional magnetic resonance imaging (fMRI) study. As a first step, we investigated the amount of fMRI volumes during rest that resembled either one of the items shown before or one of the items shown as a control after the resting period. Reactivations during both awake resting state and sleep predicted subsequent memory. These data are first evidence that spontaneous reactivation of stimulus-specific activity patterns during resting state can be investigated using MVPA. They show that reactivation occurs in humans and is behaviorally relevant for stabilizing memory traces against interference. They move beyond previous studies because replay was investigated on the level of individual stimuli and because reactivations were not evoked by sensory cues but occurred spontaneously.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.