ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Atp6ap2/(pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Soluble (Pro)Renin Receptor in Hypertension.Nephron · 2023Review
- Potential of soluble (pro)renin receptor in kidney disease: can it go beyond a biomarker?American journal of physiology. Renal physiology · 2022Review
- Endothelial cell polarity and extracellular matrix composition require functional ATP6AP2 during developmental and pathological angiogenesis.JCI insight · 2022Article
- Article
- Vacuolar-type proton ATPase is required for maintenance of apicobasal polarity of embryonic visceral endoderm.Scientific reports · 2021Article
- EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development.Investigative ophthalmology & visual science · 2021Article
- Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H.Communications biology · 2020Article
- Neuronal Signaling Involved in Neuronal Polarization and Growth: Lipid Rafts and Phosphorylation.Frontiers in molecular neuroscience · 2020Article
- The (pro)renin receptor in health and disease.Nature reviews. Nephrology · 2019Review
- Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin Receptor.Molecular therapy. Nucleic acids · 2019Article
- (Pro)renin receptor regulates lung development via the Wnt/β-catenin signaling pathway.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration.The Journal of clinical investigation · 2019Article
- (Pro)renin receptor: Involvement in diabetic retinopathy and development of molecular targeted therapy.Journal of diabetes investigation · 2019Review
- Roles and functions of Atp6ap2 in the brain.Neural regeneration research · 2018Review
- Impairment of photoreceptor ribbon synapses in a novel Pomt1 conditional knockout mouse model of dystroglycanopathy.Scientific reports · 2018Article
- The (pro)renin receptor and its interaction partners.Pflugers Archiv : European journal of physiology · 2017Review
- Atp6ap2 ablation in adult mice impairs viability through multiple organ deficiencies.Scientific reports · 2017Article
- A Novel Single-Strand RNAi Therapeutic Agent Targeting the (Pro)renin Receptor Suppresses Ocular Inflammation.Molecular therapy. Nucleic acids · 2017Article
- Receptor-associated prorenin system contributes to development of inflammation and angiogenesis in proliferative diabetic retinopathy.Inflammation and regeneration · 2016Review
- Compensatory branching morphogenesis of stalk cells in the Drosophila trachea.Development (Cambridge, England) · 2015Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(Pro)renin receptor [(P)RR], also known as Atp6ap2, has attracted growing attention as a key molecule for tissue renin-angiotensin system (RAS). In addition to its role in tissue RAS activation, Atp6ap2/(P)RR was originally identified as an accessory subunit for vacuolar H(+)-ATPase (v-ATPase), which is a multisubunit proton pump involved in diverse and fundamental cellular physiology. In this study, to elucidate the physiological function of Atp6ap2/(P)RR during retinal development in mammals, we used Cre-LoxP system to generate photoreceptor-specific conditional knock-out (CKO) mice, and revealed a critical role of Atp6ap2/(P)RR in photoreceptor development. Deletion of photoreceptor Atp6ap2/(P)RR did not affect retinal cell differentiation, but led to laminar disorganization around the outer nuclear layer together with severe dysfunction of photoreceptor cells. In the CKO mice, cell adhesion and polarity molecules, some of which were colocalized with Atp6ap2/(P)RR at the apical edge of the wild-type developing retina, were substantially dispersed together with mislocalization of retinal progenitor cells apart from the apical surface. Among theses molecules, coimmunoprecipitation using retinal homogenates and ATP6AP2/(P)RR-transfected cells showed that Atp6ap2/(P)RR interacted with partitioning defective 3 homolog (PAR3) protein, which is known to function in the Par-atypical protein kinase C (aPKC) system. Furthermore, yeast two-hybrid assays demonstrated direct molecular interaction between ATP6AP2/(P)RR and PAR3. Our present data revealed the novel function of Atp6ap2/(P)RR required for laminar formation during retinal development. We propose that this cellular activity associated with the Par-aPKC system, in addition to the v-ATPase function and tissue RAS activation, is the third biological role of Atp6ap2/(P)RR.
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