ArticleNeuro-oncology2014
Clinical and prognostic features of adult patients with gangliogliomas.
Article in Neuro-oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- EANS-EANO guidelines on the extent of resection in gliomas.Neuro-oncology · 2026Guideline
- Article
- The "long-tongue" sign: a new perspective on magnetic resonance imaging images of medullary ganglioglioma.Quantitative imaging in medicine and surgery · 2026Article
- Cerebellar ganglioglioma mimicking the radiographic appearance of Lhermitte-Duclos disease: A case report and review of literature.Radiology case reports · 2025Article
- BRAF V600E Mutation in Ganglioglioma: Impact on Epileptogenicity and Implications for Surgical Strategy.European journal of neurology · 2025Article
- Thalamic Ganglioglioma Treated With Radical Radiotherapy: A Rare Location and an Exclusive Form of Treatment.Cureus · 2024Article
- Incidence and survival characteristics of pediatric ganglioglioma from 2004 to 2018, with focus on infratentorial sites.Neuro-oncology practice · 2024Article
- Infratentorial Relapsing Neuroglial Tumors in Adults: Management and Unsolved Issues-A Systematic Review.Brain sciences · 2024Review
- Anatomy-guided resections for paralimbic tumors in the temporo-insular region: combining tumor and epilepsy surgery concepts.Frontiers in neurology · 2024Article
- Extremely slow-growing cerebellar ganglioglioma in an elderly patient.Surgical neurology international · 2024Article
- DNA methylation-based classification of glioneuronal tumours synergises with histology and radiology to refine accurate molecular stratification.Neuropathology and applied neurobiology · 2023Article
- Intraventricular ganglioglioma: a rare case report.Journal of surgical case reports · 2023Article
- Benign Glioma.Advances in experimental medicine and biology · 2023Article
- From a dysembryoplastic neuroepithelial tumor to a glioblastoma multiforme: Pitfalls of initial diagnosis on biopsy material, a case report.Surgical neurology international · 2022Article
- Low-grade gangliogliomas in adults: A population-based study.Cancer medicine · 2021Article
- Short-term outcome following surgery for rare brain tumor entities in adults: a Swedish nation-wide registry-based study and comparison with SEER database.Journal of neuro-oncology · 2020Article
- Low-grade developmental and epilepsy associated brain tumors: a critical update 2020.Acta neuropathologica communications · 2020Review
- Clinicopathologic Features of Diencephalic Neuronal and Glioneuronal Tumors.Journal of neuropathology and experimental neurology · 2020Article
- Prolonged Response Induced by Single Agent Vemurafenib in aFrontiers in oncology · 2019Article
- Impact of surgery, adjuvant treatment, and other prognostic factors in the management of anaplastic ganglioglioma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
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9 authors.
Funding
Abstract
backgroundGangliogliomas (GGs) represent <1% of primary brain tumors in adults. Little is known regarding prognostic features, clinical characteristics, or the impact of treatment on patient outcomes.
methodsOur neuro-oncology longitudinal database was screened for patients with GG from 1992 to 2012. Sixty-seven patients (age >18 y) were identified.
resultsSixty-two patients presented with low-grade GG and 5 with anaplastic GG. The median age at diagnosis was 29 years. With a median follow-up of 4.7 years after the initial diagnosis, 23 patients had progressive disease. Range of time to progression was 0.2-20 years. Nine patients with low-grade GG progressed to a malignant tumor. The median overall survival (OS) for all patients was not reached. The 2-, 5-, and 10-year OS for patients with low-grade GG were 100%, 88% (95% confidence interval [CI]: 73%, 95%), and 84% (95% CI: 67%, 93%), respectively. Factors identified by univariate analysis that were significantly associated with OS were age, KPS, extent of resection (EOR), and grade. Factors on univariate analysis that were significantly associated with progression-free survival were grade and EOR. On multicovariate Cox regression, lower tumor grade and younger age were significant factors for longer OS. EOR is a significant factor for progression-free survival.
conclusionsWhile GG has excellent prognosis, malignant histologic grade, older age, and diagnosis with biopsy could indicate worse prognosis. The late nature and high rate of progression emphasize the importance of long-term follow-up. The role of chemotherapy and radiation therapy for incompletely resected low-grade GG remains unclear.
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