ArticleJournal of neuroinflammation2013
Yokukansan promotes hippocampal neurogenesis associated with the suppression of activated microglia in Gunn rat.
Article in Journal of neuroinflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Efficacy and safety of yokukansan in treatment-resistant schizophrenia: a randomized, double-blind, placebo-controlled trial (a Positive and Negative Syndrome Scale, five-factor analysis).Psychopharmacology · 2015Trial
- Glial Cells in Behavioral and Psychological Symptoms of Alzheimer's Disease.International journal of molecular sciences · 2026Review
- Elucidating the Complex Etiology of Schizophrenia: Comprehensive Insights into the Therapeutic Roles of Natural Compounds and Pharmacological Interventions.Current pharmaceutical design · 2026Review
- The Serotonin-Mediated Anti-Allodynic Effect of Yokukansan on Paclitaxel-Induced Neuropathic Pain.Medicina (Kaunas, Lithuania) · 2024Article
- A Prospective Randomized Study of the Herbal Medicine Yokukansan for Preventing Delirium After Gastrointestinal Cancer Surgery.Yonago acta medica · 2023Article
- Glycyrrhizae Radix suppresses lipopolysaccharide- and diazepam-induced nerve inflammation in the hippocampus, and contracts the duration of pentobarbital- induced loss of righting reflex in a mouse model.Journal of natural medicines · 2023Article
- Yokukansan suppresses neuroinflammation in the hippocampus of mice and decreases the duration of lipopolysaccharide- and diazepam-mediated loss of righting reflex induced by pentobarbital.Journal of natural medicines · 2022Article
- Yokukansan Suppresses Gastric Hypersensitivity and Eosinophil-associated Microinflammation in Rats With Functional Dyspepsia.Journal of neurogastroenterology and motility · 2022Article
- Normalizing hyperactivity of the Gunn rat with bilirubin-induced neurological disorders via ketanserin.Pediatric research · 2022Article
- Kampo Formulae for the Treatment of Neuropathic Pain ∼ Especially the Mechanism of Action ofFrontiers in molecular neuroscience · 2021Review
- Effectiveness of the traditional Japanese Kampo medicine Yokukansan for chronic migraine: A case report.Medicine · 2019Article
- Article
- Analyses of the possible anti-tumor effect of yokukansan.Journal of natural medicines · 2019Article
- Gunn rats with glial activation in the hippocampus show prolonged immobility time in the forced swimming test and tail suspension test.Brain and behavior · 2018Article
- Potential Application of Yokukansan as a Remedy for Parkinson's Disease.Evidence-based complementary and alternative medicine : eCAM · 2018Review
- Traditional Japanese Herbal Medicine Yokukansan Targets Distinct but Overlapping Mechanisms in Aged Mice and in the 5xFAD Mouse Model of Alzheimer's Disease.Frontiers in aging neuroscience · 2018Article
- Yokukansan Reduces Cuprizone-Induced Demyelination in the Corpus Callosum Through Anti-inflammatory Effects on Microglia.Neurochemical research · 2017Article
- Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation.Journal of neuroinflammation · 2017Article
- Antistress effects of Kampo medicine "Yokukansan" via regulation of orexin secretion.Neuropsychiatric disease and treatment · 2017Article
- Multiple Psychopharmacological Effects of the Traditional Japanese Kampo Medicine Yokukansan, and the Brain Regions it Affects.Frontiers in pharmacology · 2017Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pathophysiology of schizophrenia (SCZ) remains unclear, and its treatment is far from ideal. We have previously reported that yokukansan (YKS), which is a traditional Japanese medicine, is effective as an adjunctive therapy for SCZ. However, the mechanisms underlying the action of YKS have not yet been completely elucidated. A recent meta-analysis study has shown that adjuvant anti-inflammatory drugs are effective for SCZ treatment, and it has been proposed that some of the cognitive deficits associated with inflammation may in part be related to inflammation-induced reductions in adult hippocampal neurogenesis. Although certain ingredients of YKS have potent anti-inflammatory activity, no study has determined if YKS has anti-inflammatory properties.
methodsUsing the Gunn rat, which has been reported as a possible animal model of SCZ, we investigated whether YKS affects cognitive dysfunction in an object-location test and the suppression of microglial activation and neurogenesis in the hippocampus.
resultsWe found that YKS ameliorated spatial working memory in the Gunn rats. Furthermore, YKS inhibited microglial activation and promoted neurogenesis in the hippocampal dentate gyrus of these rats. These results suggest that the ameliorative effects of YKS on cognitive deficits may be mediated in part by the suppression of the inflammatory activation of microglia.
conclusionsThese findings shed light on the possible mechanism underlying the efficacy of YKS in treating SCZ.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.