ArticleAge and ageing2014
C-reactive protein, APOE genotype and longitudinal cognitive change in an older population.
Article in Age and ageing, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Predictors of cognitive decline in older individuals without dementia: An updated meta-analysis.Annals of clinical and translational neurology · 2023Pooled it
- Inflammation and Cognitive Decline: A Population-Based Cohort Study Among Aging Adults With Atrial Fibrillation.Journal of the American Heart Association · 2025Article
- Longitudinal and concurrent C-reactive protein and diet associations with cognitive function in the population-based Tromsø study.Journal of Alzheimer's disease : JAD · 2025Article
- Associations of diabetes mellitus with primary open angle glaucoma and Alzheimer's disease: a large cohort study in UK biobank.Frontiers in endocrinology · 2025Article
- Article
- Statin use moderates APOE's and CRP's associations with dementia and is associated with lesser dementia severity in ε4 carriers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Alteration of Blood Immune Biomarkers in MCI Patients with DifferentInternational journal of molecular sciences · 2023Article
- High-Sensitivity C-Reactive Protein, Its Change, and Cognitive Function: A National Population-Based Cohort Study.Brain sciences · 2023Article
- Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- Limited evidence of a shared genetic relationship between C-reactive protein levels and cognitive function in older UK adults of European ancestry.Frontiers in dementia · 2023Article
- Association of Midlife Inflammatory Markers With Cognitive Performance at 10-Year Follow-up.Neurology · 2022Article
- Immune function, cortisol, and cognitive decline & dementia in an aging latino population.Psychoneuroendocrinology · 2021Observational
- Mediterranean Diet and Risk of Dementia and Alzheimer's Disease in the EPIC-Spain Dementia Cohort Study.Nutrients · 2021Article
- Article
- APOE - a genetic marker of comorbidity in subjects with morbid obesity.BMC medical genetics · 2020Article
- Apolipoprotein E genotype and the association between C-reactive protein and postoperative delirium: Importance of gene-protein interactions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- Associations of hemoglobin A1c with cognition reduced for long diabetes duration.Alzheimer's & dementia (New York, N. Y.) · 2019Article
- The protected survivor model: Using resistant successful cognitive aging to identify protection in the very old.Medical hypotheses · 2018Article
- Inflammation: Bridging Age, Menopause and APOEε4 Genotype to Alzheimer's Disease.Frontiers in aging neuroscience · 2018Review
- Systemic Inflammation Is Associated With Longitudinal Changes in Cognitive Performance Among Urban Adults.Frontiers in aging neuroscience · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundcirculating measures of inflammatory markers, such as C-reactive protein (CRP) have been associated with an increased risk of future cognitive decline. However, the nature of the relationship among the very old (>75 years) is unclear. Cross-sectional evidence suggests that elevated CRP may even be protective in this age group. This study examines these associations longitudinally.
methodslogistic regression was used to investigate the association between CRP and drop in cognitive performance (≥3 point change on the Mini-Mental State Examination) over a 4-year period in a population of 266 people, mean age 77 years.
resultsincreased levels of CRP were associated with a decreased risk of a drop in cognitive performance; however, this association was only seen in those without an APOE e4 allele [odds ratio of decline per unit increase in ln(CRP) 0.57, P = 0.04]. The magnitude of the finding remained consistent after adjustment for cardiovascular confounders (smoking, drinking, MI, stroke, diabetes, education, medication and blood pressure). For those with an e4 allele, the relationship with longitudinal cognitive decline was neither statistically significant nor in a consistent direction after controlling for acute inflammation.
conclusionsthis study strengthens previous cross-sectional findings and shows elevated levels of CRP to be linked to a decreased risk of longitudinal cognitive decline in the very old. However, as with prior analyses, this was only observed in those not carrying an APOE e4 allele. Future work on larger APOE e4 allele carrying samples is required to determine the nature of the association in this population.
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