ArticleNature communications2013
Mechanisms of leading edge protrusion in interstitial migration.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
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- The cytoplasm of living cells can sustain transient and steady intracellular pressure gradients.eLife · 2026Article
- Microtubules regulate tissue-level navigation in skin-resident macrophages.Journal of cell science · 2025Article
- Article
- Frictiotaxis underlies focal adhesion-independent durotaxis.Nature communications · 2025Article
- OsSRF8 interacts with OsINP1 and OsDAF1 to regulate pollen aperture formation in rice.Nature communications · 2024Article
- Differential response of MDA‑MB‑231 breast cancer and MCF10A normal breast cells to cytoskeletal disruption.Oncology reports · 2023Article
- Micro-engineering and nano-engineering approaches to investigate tumour ecosystems.Nature reviews. Cancer · 2023Review
- On multistability and constitutive relations of cell motion on fibronectin lanes.Biophysical journal · 2023Article
- Actin polymerization and depolymerization in developing vertebrates.Frontiers in physiology · 2023Review
- A two-step search and run response to gradients shapes leukocyte navigation in vivo.The Journal of cell biology · 2022Article
- Temperature-sensitive migration dynamics in neutrophil-differentiated HL-60 cells.Scientific reports · 2022Article
- BifA Triggers Phosphorylation of Ezrin to BenefitBiomedicines · 2022Article
- Review
- The interplay between matrix deformation and the coordination of turning events governs directed neutrophil migration in 3D matrices.Science advances · 2021Article
- Leukocyte transmigration and longitudinal forward-thrusting force in a microfluidic Transwell device.Biophysical journal · 2021Article
- The Golgi microtubules regulate single cell durotaxis.EMBO reports · 2021Article
- Biased localization of actin binding proteins by actin filament conformation.Nature communications · 2020Article
- Conserved actin machinery drives microtubule-independent motility and phagocytosis in Naegleria.The Journal of cell biology · 2020Article
- Amoeboid Swimming Is Propelled by Molecular Paddling in Lymphocytes.Biophysical journal · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
While the molecular and biophysical mechanisms underlying cell protrusion on two-dimensional substrates are well understood, our knowledge of the actin structures driving protrusion in three-dimensional environments is poor, despite relevance to inflammation, development and cancer. Here we report that, during chemotactic migration through microchannels with 5 μm × 5 μm cross-sections, HL60 neutrophil-like cells assemble an actin-rich slab filling the whole channel cross-section at their front. This leading edge comprises two distinct F-actin networks: an adherent network that polymerizes perpendicular to cell-wall interfaces and a 'free' network that grows from the free membrane at the cell front. Each network is polymerized by a distinct nucleator and, due to their geometrical arrangement, the networks interact mechanically. On the basis of our experimental data, we propose that, during interstitial migration, medial growth of the adherent network compresses the free network preventing its retrograde movement and enabling new polymerization to be converted into forward protrusion.
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