Evidence map›Paper›PMID 24305612›Full record

ArticleInternational journal of impotence research

Oral Bisphenol A (BPA) given to rats at moderate doses is associated with erectile dysfunction, cavernosal lipofibrosis and alterations of global gene transcription.

I Kovanecz, R Gelfand, M Masouminia, S Gharib, D Segura, D Vernet, J Rajfer, D K Li, K Kannan, N F Gonzalez-Cadavid

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of impotence research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Bisphenol F Exposure in Adolescent Heterogeneous Stock Rats Affects Growth and Adiposity.Toxicological sciences : an official journal of the Society of Toxicology · 2021
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Bisphenol A Impairs Synaptic Plasticity by Both Pre- and Postsynaptic Mechanisms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2017
    Article
  11. Epigenetic impacts of endocrine disruptors in the brain.Frontiers in neuroendocrinology · 2017
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2015
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

I Kovanecz1] Division of Urology, Department of Surgery, Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute, Torrance, CA, USA [2] Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
R Gelfand1] Division of Urology, Department of Surgery, Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute, Torrance, CA, USA [2] Division of Endocrinology, Charles Drew University of Medicine and Science, Los Angeles, CA, USA.
M MasouminiaDivision of Urology, Department of Surgery, Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute, Torrance, CA, USA.
S GharibDivision of Urology, Department of Surgery, Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute, Torrance, CA, USA.
D SeguraDivision of Urology, Department of Surgery, Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute, Torrance, CA, USA.
D Vernet1] Division of Urology, Department of Surgery, Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute, Torrance, CA, USA [2] Division of Endocrinology, Charles Drew University of Medicine and Science, Los Angeles, CA, USA.
J Rajfer1] Division of Urology, Department of Surgery, Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute, Torrance, CA, USA [2] Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
D K Li1] Department of Health Research and Policy, Stanford University, Stanford, CA, USA [2] Division of Research, Kaiser Permanente, Oakland, CA, USA.
K KannanWadsworth Center, New York State Department of Health, Albany, NY, USA.
N F Gonzalez-Cadavid1] Division of Urology, Department of Surgery, Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute, Torrance, CA, USA [2] Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA [3] Division of Endocrinology, Charles Drew University of Medicine and Science, Los Angeles, CA, USA.
Harbor–UCLA Medical Center · USThe Lundquist Institute · USNew York State Department of Health · USStanford University · USUniversity of California, Los Angeles · US

Funding

BISPHENOL A EFFECTS ON THE PERIPHERAL MECHANISMS OF PENILE ERECTIONR21ES019465 · NIEHS · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI GONZALEZ-CADAVID, NESTOR F · 2010 to 2011
$433k
Cellular-molecular signature and mechanism of BPA effects on penil erectionU01ES020887 · NIEHS · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI GONZALEZ-CADAVID, NESTOR F · 2011 to 2014
$282k
NIEHS NIH HHS 1U01ES020887NIEHS NIH HHS R21 ES019465NIEHS NIH HHS R21ES019465NIEHS NIH HHS U01 ES020887
6 · The paper itself

Abstract

Bisphenol A (BPA), a suspected reproductive biohazard and endocrine disruptor, released from plastics is associated with ED in occupationally exposed workers. However, in rats, despite the induction of hypogonadism, apoptosis of the penile corporal smooth muscle (SM), fat infiltration into the cavernosal tissue and changes in global gene expression with the intraperitoneal administration of high dose BPA, ED was not observed. We investigated whether BPA administered orally rather than intraperitoneally to rats for longer periods and lower doses will lead to ED. Main outcome measures are ED, histological, and biochemical markers in rat penile tissues. In all, 2.5-month-old rats were given drinking water daily without and with BPA at 1 and 0.1 mg kg(-1) per day. Two months later, erectile function was determined by cavernosometry and electrical field stimulation (EFS) and serum levels of testosterone (T), estradiol (E2) and BPA were measured. Penile tissue sections were assayed by Masson (SM/collagen), Oil Red O (fat), terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) (apoptosis), immunohistochemistry for Oct4 (stem cells), and α-SM actin/calponin (SM and myofibroblasts), applying quantitative image analysis. Other markers were assayed by western blotting. DNA microarrays/microRNA (miR) assays defined transcription profiles. Orally administered BPA did not affect body weight, but (1) decreased serum T and E2; (2) reduced the EFS response and increased the drop rate; (3) increased within the corporal tissue the presence of fat, myofibroblasts and apoptosis; (4) lowered the contents of SM and stem cells, but not nerve terminals; and (5) caused alterations in the transcriptional profiles for both mRNA and miRs within the penile shaft. Long-term exposure of rats to oral BPA caused a moderate corporal veno-occlusive dysfunction (CVOD), possibly due to alterations within the corporal tissue that pose gene transcriptional changes related to inflammation, fibrosis and epithelial/mesenchymal transition (EMT).

Indexed as

Administration, OralAnimalsBenzhydryl CompoundsBisphenol A CompoundsElectric StimulationErectile DysfunctionEstradiolEstrogens, Non-SteroidalGene ExpressionMaleMicroRNAsMuscle, SmoothPenisPhenolsRatsRats, Inbred F344Benzhydryl Compoundsbisphenol ABisphenol A CompoundsEstradiolEstrogens, Non-SteroidalMicroRNAsPhenolsTestosterone

Identifiers

PMID24305612
PMCPMC4098849
OpenAlexW1978496609

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.