ArticlePlant signaling & behavior2013
Old AIMs of the exocyst: evidence for an ancestral association of exocyst subunits with autophagy-associated Atg8 proteins.
Article in Plant signaling & behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Electrostatic changes enabled the diversification of an exocyst subunit via protein complex escape.Nature plants · 2025Article
- Regulatory roles of selective autophagy through targeting of native proteins in plant adaptive responses.Plant cell reports · 2022Review
- Exocyst subunit Exo70B2 is linked to immune signaling and autophagy.The Plant cell · 2021Article
- Review
- EXO70D isoforms mediate selective autophagic degradation of type-A ARR proteins to regulate cytokinin sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- AtNBR1 Is a Selective Autophagic Receptor for AtExo70E2 in Arabidopsis.Plant physiology · 2020Article
- Article
- Evolution of late steps in exocytosis: conservation and specialization of the exocyst complex.Wellcome open research · 2019Article
- TheFrontiers in plant science · 2019Article
- Article
- Constitutive Negative Regulation of R Proteins in Arabidopsis also via Autophagy Related Pathway?Frontiers in plant science · 2016Article
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2 authors.
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Abstract
In a recent addendum, Oren Tzfadia and Gad Galili (PSB 2014; 9:e26732) showed that several Arabidopsis exocyst subunits possess consensus Atg8-interacting motifs (AIMs), which may mediate their interaction with the autophagy-associated Atg8 protein, providing thus a mechanistic base for participation of exocyst (sub)complexes in autophagy. However, the bioinformatically identified AIMs are short peptide motifs that may occur by chance. We thus performed an exhaustive search in a large collection of plant exocyst-derived sequences from our previous bioinformatic study and found that AIMs are over-represented among exocyst subunits of all lineages examined, including moss and club moss, compared with a representative sample of the Arabidopsis proteome. This is consistent with the proposed exocyst AIMs being biologically meaningful and evolutionarily ancient. Moreover, among the numerous EXO70 paralogs, the monocot-specific EXO70F clade appears to be exempt from the general AIM enrichment, suggesting a modification of the autophagy connection in a subset of exocyst variants.
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